Gary Ewart:
ORCID: https://orcid.org/0000-0001-5919-8275
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Writing – original
draftRole: Writing – review & editing
Michael Bobardt: Role: Data curationRole: InvestigationRole: Methodology
Bo Hjorth Bentzen: Role: Data curationRole: Formal analysisRole: InvestigationRole: Methodology
Yannan Yan: Role: Investigation
Audrey Thomson: Role: Project administrationRole: Writing – original draft
Klaus Klumpp: Role: ConceptualizationRole: MethodologyRole: Writing – original draftRole: Writing
– review & editing
Stephen Becker: Role: Writing – review & editing
Mette M. Rosenkilde: Role: ConceptualizationRole: Data curationRole: InvestigationRole: Writing – review
& editing
Michelle Miller: Role: ConceptualizationRole: Funding acquisitionRole: Project administrationRole:
Writing – review & editing
Philippe Gallay: Role: ConceptualizationRole: Data curationRole: InvestigationRole: MethodologyRole:
Project administration
Nicholas Heaton: Role: Editor
Journal ID (nlm-ta): PLoS Pathog
Journal ID (iso-abbrev): PLoS Pathog
Journal ID (publisher-id): plos
Title:
PLOS Pathogens
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-7366
ISSN
(Electronic):
1553-7374
Publication date
(Electronic):
7
August
2023
Publication date Collection:
August
2023
Volume: 19
Issue: 8
Electronic Location Identifier: e1011328
Affiliations
[1
]
Biotron Limited, North Ryde, New South Wales, Australia
[2
]
The Scripps Institute, Immunology and Microbiology, La Jolla, California, United States
of America
[3
]
University of Copenhagen, Department of Biomedical Sciences, Copenhagen, Denmark
Duke University, UNITED STATES
Author notes
GE, AT and MM are employees of Biotron Limited; KK and SB are consultants of Biotron
Limited. MMR is co-founder, member of the Board of Directors and minority shareholder
of Synklino.
Author information
Article
Publisher ID:
PPATHOGENS-D-23-00564
DOI: 10.1371/journal.ppat.1011328
PMC ID: 10434922
PubMed ID: 37549173
SO-VID: 71297e12-f7c0-455a-92d0-3b55d48f55cc
Copyright © © 2023 Ewart et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by:
Biotron Limited
Funded by:
funder-id http://dx.doi.org/10.13039/100019180, HORIZON EUROPE European Research Council;
Award ID: 682549
Award Recipient
:
Mette M. Rosenkilde
Funded by:
funder-id http://dx.doi.org/10.13039/501100003554, Lundbeck Foundation;
Award ID: lR242-2017-409
Award Recipient
:
Mette M. Rosenkilde
Funded by:
funder-id http://dx.doi.org/10.13039/501100009708, Novo Nordisk Fonden;
Award ID: NNF20OC0062899
Award Recipient
:
Mette M. Rosenkilde
The work was entirely funded by Biotron Limited, with the exception of the Xenopus
oocyte experiments, which received funding from the European Research Council (ERC)
under the European Union’s Horizon 2020 research and innovation programme (grant agreement
No 682549 to MMR), the Lundbeck Foundation (lR242-2017-409 to MMR) and the NovoNordisk
Foundation (NNF20OC0062899 to MMR). MM, GE and AT are full time employees of Biotron,
and the study design, data analyses, publication decision and manuscript preparation
were all undertaken in conjunction with the other authors.
Subject:
Research Article
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Coronaviruses
Subject:
SARS coronavirus
Subject:
SARS CoV 2
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Coronaviruses
Subject:
SARS coronavirus
Subject:
SARS CoV 2
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Coronaviruses
Subject:
SARS coronavirus
Subject:
SARS CoV 2
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral pathogens
Subject:
Coronaviruses
Subject:
SARS coronavirus
Subject:
SARS CoV 2
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Mouse Models
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancer Treatment
Subject:
Cytokine Therapy
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Xenopus
Subject:
Xenopus Oocytes
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Xenopus
Subject:
Xenopus Oocytes
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Xenopus
Subject:
Xenopus Oocytes
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Eukaryota
Subject:
Animals
Subject:
Vertebrates
Subject:
Amphibians
Subject:
Frogs
Subject:
Xenopus
Subject:
Xenopus Oocytes
Subject:
Biology and Life Sciences
Subject:
Zoology
Subject:
Animals
Subject:
Vertebrates
Subject:
Amphibians
Subject:
Frogs
Subject:
Xenopus
Subject:
Xenopus Oocytes
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Virology
Subject:
Viral Transmission and Infection
Subject:
Viral Load
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Cytokines
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune System
Subject:
Innate Immune System
Subject:
Cytokines
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune System
Subject:
Innate Immune System
Subject:
Cytokines
Subject:
Biology and Life Sciences
Subject:
Developmental Biology
Subject:
Molecular Development
Subject:
Cytokines
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Vaccination and Immunization
Subject:
Antiviral Therapy
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Vaccination and Immunization
Subject:
Antiviral Therapy
Subject:
Medicine and Health Sciences
Subject:
Public and Occupational Health
Subject:
Preventive Medicine
Subject:
Vaccination and Immunization
Subject:
Antiviral Therapy
Subject:
Biology and Life Sciences
Subject:
Biophysics
Subject:
Ion Channels
Subject:
Physical Sciences
Subject:
Physics
Subject:
Biophysics
Subject:
Ion Channels
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Electrophysiology
Subject:
Ion Channels
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Electrophysiology
Subject:
Neurophysiology
Subject:
Ion Channels
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Neurophysiology
Subject:
Ion Channels
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Ion Channels
