ScienceOpen: research and publishing network

For Researchers

Search
Advanced search

1

views

    

0

recommends

0

shares

Record: found
Abstract: found
Article: found

Is Open Access

Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study

research-article

Author(s): Jamie W. Bellinge , MBBS ¹ ^, ² , Frederik Dalgaard , MD, PhD ³ , Kevin Murray , PhD ⁴ , Emma Connolly , BNutrDiet (Hons) ⁵ , Lauren C. Blekkenhorst , PhD ¹ ^, ⁵ , Catherine P. Bondonno , PhD ¹ ^, ⁵ , Joshua R. Lewis , PhD ¹ ^, ⁵ ^, ⁶ , Marc Sim , PhD ¹ ^, ⁵ , Kevin D. Croft , PhD ⁷ , Gunnar Gislason , MD, PhD ³ ^, ⁸ ^, ⁹ , Christian Torp‐Pedersen , MD, DMSc ¹⁰ ^, ¹¹ , Anne Tjønneland , MD, PhD ¹² ^, ¹³ , Kim Overvad , MD, PhD ¹¹ ^, ¹⁴ , Jonathan M. Hodgson , PhD ¹ ^, ⁵ , Carl Schultz , MBChB, PhD ¹ ^, ² , Nicola P. Bondonno , PhD ⁵ ^, ⁷ ^, ¹² ^,

Publication date (Electronic): 07 August 2021

Journal: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Publisher: John Wiley and Sons Inc.

Keywords: atherosclerotic cardiovascular disease, dietary vitamin K, phylloquinone, menaquinone, primary prevention, prospective cohort study, Cardiovascular Disease, Epidemiology, Diet and Nutrition, Primary Prevention

Read this article at

ScienceOpen Publisher PMC

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Background

Dietary vitamin K (K ₁ and K ₂) may reduce atherosclerotic cardiovascular disease (ASCVD) risk via several mechanisms. However, studies linking vitamin K intake with incident ASCVD are limited. We aimed to determine the relationship between dietary vitamin K intake and ASCVD hospitalizations.

Methods and Results

In this prospective cohort study, participants from the Danish Diet, Cancer, and Health Study, with no prior ASCVD, completed a food‐frequency questionnaire at baseline and were followed up for hospital admissions of ASCVD; ischemic heart disease, ischemic stroke, or peripheral artery disease. Intakes of vitamin K ₁ and vitamin K ₂ were estimated from the food‐frequency questionnaire, and their relationship with ASCVD hospitalizations was determined using Cox proportional hazards models. Among 53 372 Danish citizens with a median (interquartile range) age of 56 (52–60) years, 8726 individuals were hospitalized for any ASCVD during 21 (17–22) years of follow‐up. Compared with participants with the lowest vitamin K ₁ intakes, participants with the highest intakes had a 21% lower risk of an ASCVD‐related hospitalization (hazard ratio, 0.79; 95% CI: 0.74–0.84), after multivariable adjustments for relevant demographic covariates. Likewise for vitamin K ₂, the risk of an ASCVD‐related hospitalization for participants with the highest intakes was 14% lower than participants with the lowest vitamin K ₂ intake (hazard ratio, 0.86; 95% CI, 0.81–0.91).

Conclusions

Risk of ASCVD was inversely associated with diets high in vitamin K ₁ or K ₂. The similar inverse associations with both vitamin K ₁ and K ₂, despite very different dietary sources, highlight the potential importance of vitamin K for ASCVD prevention.

Related collections

Most cited references 50

Record: found
Abstract: found
Article: not found

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.

Paul M Ridker, Brendan M. Everett, Tom Thuren … (2017)

Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved.

0 comments Cited 2106 times – based on 0 reviews      Review now

Record: found
Abstract: found
Article: found

Is Open Access

The Danish National Patient Registry: a review of content, data quality, and research potential

Morten Schmidt, Sigrun Alba Johannesdottir Schmidt, Jakob Sandegaard … (2015)

Background The Danish National Patient Registry (DNPR) is one of the world’s oldest nationwide hospital registries and is used extensively for research. Many studies have validated algorithms for identifying health events in the DNPR, but the reports are fragmented and no overview exists. Objectives To review the content, data quality, and research potential of the DNPR. Methods We examined the setting, history, aims, content, and classification systems of the DNPR. We searched PubMed and the Danish Medical Journal to create a bibliography of validation studies. We included also studies that were referenced in retrieved papers or known to us beforehand. Methodological considerations related to DNPR data were reviewed. Results During 1977–2012, the DNPR registered 8,085,603 persons, accounting for 7,268,857 inpatient, 5,953,405 outpatient, and 5,097,300 emergency department contacts. The DNPR provides nationwide longitudinal registration of detailed administrative and clinical data. It has recorded information on all patients discharged from Danish nonpsychiatric hospitals since 1977 and on psychiatric inpatients and emergency department and outpatient specialty clinic contacts since 1995. For each patient contact, one primary and optional secondary diagnoses are recorded according to the International Classification of Diseases. The DNPR provides a data source to identify diseases, examinations, certain in-hospital medical treatments, and surgical procedures. Long-term temporal trends in hospitalization and treatment rates can be studied. The positive predictive values of diseases and treatments vary widely (<15%–100%). The DNPR data are linkable at the patient level with data from other Danish administrative registries, clinical registries, randomized controlled trials, population surveys, and epidemiologic field studies – enabling researchers to reconstruct individual life and health trajectories for an entire population. Conclusion The DNPR is a valuable tool for epidemiological research. However, both its strengths and limitations must be considered when interpreting research results, and continuous validation of its clinical data is essential.

0 comments Cited 1147 times – based on 0 reviews      Review now

Record: found
Abstract: found
Article: not found

Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies

The Emerging Risk Factors Collaboration, George Davey Smith (2011)

Summary Background Uncertainties persist about the magnitude of associations of diabetes mellitus and fasting glucose concentration with risk of coronary heart disease and major stroke subtypes. We aimed to quantify these associations for a wide range of circumstances. Methods We undertook a meta-analysis of individual records of diabetes, fasting blood glucose concentration, and other risk factors in people without initial vascular disease from studies in the Emerging Risk Factors Collaboration. We combined within-study regressions that were adjusted for age, sex, smoking, systolic blood pressure, and body-mass index to calculate hazard ratios (HRs) for vascular disease. Findings Analyses included data for 698 782 people (52 765 non-fatal or fatal vascular outcomes; 8·49 million person-years at risk) from 102 prospective studies. Adjusted HRs with diabetes were: 2·00 (95% CI 1·83–2·19) for coronary heart disease; 2·27 (1·95–2·65) for ischaemic stroke; 1·56 (1·19–2·05) for haemorrhagic stroke; 1·84 (1·59–2·13) for unclassified stroke; and 1·73 (1·51–1·98) for the aggregate of other vascular deaths. HRs did not change appreciably after further adjustment for lipid, inflammatory, or renal markers. HRs for coronary heart disease were higher in women than in men, at 40–59 years than at 70 years and older, and with fatal than with non-fatal disease. At an adult population-wide prevalence of 10%, diabetes was estimated to account for 11% (10–12%) of vascular deaths. Fasting blood glucose concentration was non-linearly related to vascular risk, with no significant associations between 3·90 mmol/L and 5·59 mmol/L. Compared with fasting blood glucose concentrations of 3·90–5·59 mmol/L, HRs for coronary heart disease were: 1·07 (0·97–1·18) for lower than 3·90 mmol/L; 1·11 (1·04–1·18) for 5·60–6·09 mmol/L; and 1·17 (1·08–1·26) for 6·10–6·99 mmol/L. In people without a history of diabetes, information about fasting blood glucose concentration or impaired fasting glucose status did not significantly improve metrics of vascular disease prediction when added to information about several conventional risk factors. Interpretation Diabetes confers about a two-fold excess risk for a wide range of vascular diseases, independently from other conventional risk factors. In people without diabetes, fasting blood glucose concentration is modestly and non-linearly associated with risk of vascular disease. Funding British Heart Foundation, UK Medical Research Council, and Pfizer.

0 comments Cited 902 times – based on 0 reviews      Review now

Author and article information

Contributors

Nicola P. Bondonno:

ORCID: https://orcid.org/0000-0001-5905-444X

n.bondonno@ecu.edu.au

Journal

Journal ID (nlm-ta): J Am Heart Assoc

Journal ID (iso-abbrev): J Am Heart Assoc

Journal ID (doi): 10.1002/(ISSN)2047-9980

Journal ID (publisher-id): JAH3

Journal ID (hwp): ahaoa

Title: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Publisher: John Wiley and Sons Inc. (Hoboken )

ISSN (Electronic): 2047-9980

Publication date (Electronic): 07 August 2021

Publication date Collection: 17 August 2021

Volume: 10

Issue: 16 ( doiID: 10.1002/jah3.v10.16 )

Electronic Location Identifier: e020551

Affiliations

[ ¹ ] School of Medicine University of Western Australia Perth Australia

[ ² ] Department of Cardiology Royal Perth Hospital Perth Australia

[ ³ ] Department of Cardiology Herlev & Gentofte University Hospital Copenhagen Denmark

[ ⁴ ] School of Population and Global Health University of Western Australia Perth WA Australia

[ ⁵ ] Institute for Nutrition Research School of Medical and Health Sciences Edith Cowan University Perth Australia

[ ⁶ ] Centre for Kidney Research Children's Hospital at Westmead School of Public Health Sydney Medical School The University of Sydney Sydney NSW Australia

[ ⁷ ] School of Biomedical Sciences University of Western Australia Royal Perth Hospital Perth WA Australia

[ ⁸ ] The National Institute of Public Health University of Southern Denmark Odense Denmark

[ ⁹ ] The Danish Heart Foundation Copenhagen Denmark

[ ¹⁰ ] Department of Clinical Investigation and Cardiology Nordsjælland Hospital Hillerød Denmark

[ ¹¹ ] Department of Public Health Aarhus University Aarhus Denmark

[ ¹² ] The Danish Cancer Society Research Centre Copenhagen Denmark

[ ¹³ ] Department of Public Health University of Copenhagen Copenhagen Denmark

[ ¹⁴ ] Aalborg University Hospital Aalborg Denmark

Author notes

[*] [* ] Correspondence to: Nicola P. Bondonno, PhD, Level 3, Medical Research Foundation, Rear 50 Murray St, Perth, Western Australia 6000, Australia. E‐mail: n.bondonno@ 123456ecu.edu.au

J. W. Bellinge and F. Dalgaard contributed equally to this work.

Author information

Jamie W. Bellinge https://orcid.org/0000-0001-8257-7361

Frederik Dalgaard https://orcid.org/0000-0002-7287-4191

Kevin Murray https://orcid.org/0000-0002-8856-6046

Lauren C. Blekkenhorst https://orcid.org/0000-0003-1561-9052

Catherine P. Bondonno https://orcid.org/0000-0001-8509-439X

Joshua R. Lewis https://orcid.org/0000-0003-1003-8443

Marc Sim https://orcid.org/0000-0001-5166-0605

Gunnar Gislason https://orcid.org/0000-0002-0548-402X

Jonathan M. Hodgson https://orcid.org/0000-0001-6184-7764

Carl Schultz https://orcid.org/0000-0002-0847-4361

Nicola P. Bondonno https://orcid.org/0000-0001-5905-444X

Article

Publisher ID: JAH36611

DOI: 10.1161/JAHA.120.020551

PMC ID: 8475061

PubMed ID: 34369182

SO-VID: 7218e893-e759-4706-807b-2fca604bced3

Copyright © © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

License:

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

History

Date received : 16 December 2020

Date accepted : 07 July 2021

Page count

Figures: 3, Tables: 2, Pages: 12, Words: 19777

Categories

Subject: Original Research

Subject: Original Research

Subject: Epidemiology

Custom metadata

source-schema-version-number 2.0

cover-date August 17, 2021

details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:6.0.5 mode:remove_FC converted:17.08.2021

ScienceOpen disciplines: Cardiovascular Medicine

Keywords: atherosclerotic cardiovascular disease,dietary vitamin k,phylloquinone,menaquinone,primary prevention,prospective cohort study,cardiovascular disease,epidemiology,diet and nutrition

Data availability:

ScienceOpen disciplines: Cardiovascular Medicine

Keywords: atherosclerotic cardiovascular disease, dietary vitamin k, phylloquinone, menaquinone, primary prevention, prospective cohort study, cardiovascular disease, epidemiology, diet and nutrition

Comments

Comment on this article

scite_

Similar content 201

See all similar

Cited by 9

See all cited by

Most referenced authors 861

See all reference authors

- Version 1