There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto"
id="d10237864e93">The secretome refers to all the Excreted/Secreted (ES) proteins
of a cell, and these
are involved in critical biological processes, such as cell-cell communication, and
host immune responses. Recently, we introduced the Abundance of Antigenic Aegions
(AAR) value to assess the protein antigenic density and to evaluate the antigenic
potential of secretomes. Here, to facilitate the AAR calculation, we implemented it
as a user-friendly webserver. We extended the webserver capabilities implementing
a sequence-based tool for searching homologous proteins across secretomes, including
experimental and predicted secretomes of Mycobacterium tuberculosis and Taenia solium.
Additionally, twelve secretomes of helminths, five of Mycobacterium and two of Gram-negative
bacteria are also available. Our webserver is a useful tool for researchers working
on immunoinformatics and reverse vaccinology, aiming at discovering candidate proteins
for new vaccines or diagnostic tests, and it can be used to prioritize the experimental
analysis of proteins for druggability assays. The Secret-AAR web server is available
at http://microbiomics.ibt.unam.mx/tools/aar/.
</p>