Role of Sympathetic Nerves in Disposition and Metabolism of Intraluminal and Extraluminal Noradrenaline in the Rabbit Ear Artery

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Abstract

Rabbit ear arteries were perfused extraluminally or intraluminally with noradrenaline (NA) 0.18 µmol/l for 30 min. The extraluminal NA taken up was largely accumulated in the artery; 3,4-dihydroxymandelic acid (DOPEG) and normetanephrine (NMN) were the principle metabolites. The intraluminal NA taken up was largely O-methylated to NMN, the formation of NMN exceeding that from extraluminal NA by a factor of 2.6; DOPEG was formed in trace amounts only. Sympathectomy eliminated DOPEG formation and abolished the influence of the surface of entry on O-methylation by selectively increasing NMN formation from extraluminal NA without affecting the formation from intraluminal NA. Cocaine (30 µmol/l) was without effect on metabolite formation from extraluminal NA in sympathectomized arteries. The results (a) confirm earlier evidence obtained on reserpinized arteries which indicated that the sympathetic nerves play an important role in the disposition and metabolism of NA only when the amine enters via the adventitial surface, and (b) argue against the possibility that cocaine exerts an extraneuronal action on metabolism of NA in this vessel.

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Author and article information

Journal

Journal ID (publisher-id): JVR

Journal ID (nlm-ta): J Vasc Res

Journal ID (doi): 10.1159/issn.1018-1172

Title: Journal of Vascular Research

Publisher: S. Karger AG

ISSN (Print): 1018-1172

ISSN (Electronic): 1423-0135

Publication date Subscription-year: 1988

Publication date (Print): 1988

Publication date (Electronic): 23 September 2008

Volume: 25

Issue: 5

Pages: 232-239

Affiliations

Department of Clinical and Experimental Pharmacology, University of Adelaide, Australia

Article

Publisher ID: 158735 Other ID: Blood Vessels 1988;25:232–239

DOI: 10.1159/000158735

SO-VID: 74249763-ce4d-482a-bf20-66b457be9e2e

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 08 June 1987

Date accepted : 23 October 1987

Page count

Pages: 8

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