Associations of diabetes mellitus, insulin, leptin, and ghrelin with gastroesophageal reflux and Barrett's esophagus.

Rubenstein, Joel H; Morgenstern, Hal; McConell, Daniel; Scheiman, James M; Schoenfeld, Philip; Appelman, Henry; McMahon, Laurence F; Kao, John Y; Metko, Val; Zhang, Min; Inadomi, John M

doi:10.1053/j.gastro.2013.08.052

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Associations of diabetes mellitus, insulin, leptin, and ghrelin with gastroesophageal reflux and Barrett's esophagus.

Author(s): Joel H Rubenstein ¹ , Hal Morgenstern , Daniel McConell , James M Scheiman , Philip Schoenfeld , Henry Appelman , Laurence F McMahon , John Y Kao , Val Metko , Min Zhang , John M Inadomi

Publication date (Electronic): Dec 2013

Journal: Gastroenterology

Keywords: BE, Barrett's esophagus, CI, CRC, GERD, Gastroesophageal Reflux, Ghrelin, Insulin, LA, Leptin, Los Angeles, OR, PPI, colorectal cancer, confidence interval, gastroesophageal reflux disease, odds ratio, proton pump inhibitor

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Abstract

Insulin and leptin have proliferative and anti-apoptotic effects. Ghrelin promotes gastric emptying and secretion of growth hormone and inhibits inflammation. We assessed whether diabetes mellitus and serum levels of insulin, leptin, and ghrelin are associated with gastroesophageal reflux disease (GERD) and Barrett's esophagus.

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Journal ID (iso-abbrev): Gastroenterology

Title: Gastroenterology

ISSN (Electronic): 1528-0012

ISSN (Print): 0016-5085

Publication date (Electronic): Dec 2013

Volume: 145

Issue: 6

Affiliations

[1 ] Center for Clinical Management Research, Ann Arbor Veterans Affairs Medical Center, Ann Arbor, Michigan; Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan. Electronic address: jhr@umich.edu.

Article

Publisher Item ID: S0016-5085(13)01272-9 Mid ID: NIHMS535438

DOI: 10.1053/j.gastro.2013.08.052

PubMed ID: 23999171

SO-VID: 747b0879-aca3-44cc-b4e9-9c5c5d638fad

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Keywords: BE,Barrett's esophagus,CI,CRC,GERD,Gastroesophageal Reflux,Ghrelin,Insulin,LA,Leptin,Los Angeles,OR,PPI,colorectal cancer,confidence interval,gastroesophageal reflux disease,odds ratio,proton pump inhibitor

Associations of diabetes mellitus, insulin, leptin, and ghrelin with gastroesophageal reflux and Barrett's esophagus.

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Karger: Gastroenterology

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