Gene expression analysis of Arc mRNA as a neuronal cell activity marker in the hippocampus and amygdala in two-way active avoidance test in rats.

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Abstract

Immediate early genes are widely used as neuronal cell activity markers in neuroscience. The present study investigated the relationship between their expression and abnormality in context fear conditioning.

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Author and article information

Journal

Journal ID (iso-abbrev): J Pharmacol Toxicol Methods

Title: Journal of pharmacological and toxicological methods

Publisher: Elsevier BV

ISSN (Electronic): 1873-488X

ISSN (Print): 1056-8719

Publication date (Electronic): 2017

Volume: 88

Issue: Pt 2

Affiliations

[1 ] Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., 1-16-13 Kita-Kasai, Edogawa-ku, Tokyo 134-8630, Japan. Electronic address: yasuno.kyohei.ss@daiichisankyo.co.jp.

[2 ] Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., 1-16-13 Kita-Kasai, Edogawa-ku, Tokyo 134-8630, Japan. Electronic address: takahashi.erika.f5@daiichisankyo.co.jp.

[3 ] Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., 1-16-13 Kita-Kasai, Edogawa-ku, Tokyo 134-8630, Japan. Electronic address: igarashi.isao.t6@daiichisankyo.co.jp.

[4 ] Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., 1-16-13 Kita-Kasai, Edogawa-ku, Tokyo 134-8630, Japan. Electronic address: iguchi.takuma.kz@daiichisankyo.co.jp.

[5 ] Global Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo Pharma Development, 211 Mt. Airy Road, Basking Ridge, NJ 07920, USA. Electronic address: ytsuchiya@dsi.com.

[6 ] Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., 1-16-13 Kita-Kasai, Edogawa-ku, Tokyo 134-8630, Japan. Electronic address: kai.kiyonori.xb@daiichisankyo.co.jp.

[7 ] Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., 1-16-13 Kita-Kasai, Edogawa-ku, Tokyo 134-8630, Japan. Electronic address: mori.kazuhiko.md@daiichisankyo.co.jp.