DILI Cases in Registries and Databases: An Analysis of Quality

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Abstract

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Data quality of idiosyncratic drug-induced liver injury (iDILI) cases is insufficient in the US LiverTox database due to the lack of a robust causality assessment method such as the Roussel Uclaf Causality Assessment Method (RUCAM), not allowing for appropriate use of included cases by physicians. Despite some shortcomings, case quality is much better in national DILI registries using the prospective RUCAM, with a few exemptions.

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Journal

Title: The International Journal of Gastroenterology and Hepatology Diseases

Abbreviated Title: IJGHD

Publisher: Bentham Science Publishers Ltd.

ISSN (Print): 26662906

Publication date Created: March 2022

Publication date (Print): March 2022

Volume: 1

Issue: 1

Affiliations

[1 ]Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, D-63450 Hanau, Academic Teaching Hospital of the Medical Faculty, Goethe University Frankfurt/ Main, Frankfurt/Main, Germany

[2 ]Pharmacovigilance Consultancy, Paris, France

Article

DOI: 10.2174/2666290601666210325091553

SO-VID: 75c07ea4-32b0-4bf2-a5b0-86465f57a955

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