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      Endovascular aortic repairs combined with looping-chimney technique for repairing aortic arch lesions and reconstructing left common carotid artery

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          Abstract

          Background

          The aim of this retrospective study was to evaluate the feasibility and efficacy of thoracic endovascular aortic repairs (TEVAR) combined with looping chimney technique (LCT) for repairing aortic arch lesions and reconstructing left common carotid artery.

          Methods

          Total of 14 patients (mean age 52.86±14.46 years; range, 27–79; 10 men, 4 women) were included in the study from December 2016 to December 2018. Aortic arch pathologies of all patients with insufficient proximal landing zone (PLZ) were repaired by TEVAR under local anesthesia, before TEVAR, the left common carotid artery (LCCA) was protected by the guiding sheath from the retrograde brachial access, after aortic stent graft deployed, chimney graft was implanted to restore LCCA by LCT if necessary. All patients underwent computed tomography angiograph (CTA) 2 weeks, 3 months, 6 months and 1 year after surgery.

          Results

          Pathology results of 14 patients included: type B aortic dissection (n=8), penetrating aortic ulcers (n=1), retrograde type A aortic dissection (n=1), thoracic aortic aneurysm (TAA) (n=2), and thoracic aortic pseudoaneurysm (n=2). In all patients, aortic arch lesions were repaired by TEVAR; while LCCA were successfully reconstructed by the LCT. In one case, the innominate artery (IA) was simultaneously reconstructed through the same percutaneous right brachial artery (RBA) access. Coiling eliminated type Ia endoleak in 3 patients, and type II endoleak vanished by plugging left subclavian artery (LSA) in 2 patients. In four patients, the chimney stent (CG) of LCCA was partially compressed and then another bare stent was implanted to restore patency rate. The mean follow-up duration was 9.77±6.64 months (range, 0–24) and no combinations were observed in 13 patients; except in one patient who died of cerebral hemorrhage due to abnormal coagulation function.

          Conclusions

          TEVAR combined with LCT has shown to be suitable surgical approach for aortic arch lesions. Either covered intentionally or inadvertently, the LCCA could be safely and effectively reconstructed via percutaneous RBA access. Short-term follow-up demonstrated satisfactory morbidity and mortality in high-risk patients; however, longer follow-up is required to assess the effectiveness and durability of this innovative endovascular procedure.

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          Most cited references39

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          Retrograde type A aortic dissection after endovascular stent graft placement for treatment of type B dissection.

          Retrograde type A aortic dissection has been deemed a rare complication after endovascular stent graft placement for type B dissection. However, this life-threatening event appears to be underrecognized and is worth being investigated further. Eleven of 443 patients developed retrograde type A aortic dissection during or after stent grafting for type B dissection from August 2000 to June 2007. Of these 11 patients, 3 had Marfan syndrome. The Kaplan-Meier estimate of the rate of freedom from this event at 36 months is 97.4% (95% confidence interval, 0.95 to 0.99). The new entry was located at the tip of the proximal bare spring of the stent graft in 9 patients, was within the anchoring area of the proximal bare spring in 1, and remained unknown in 1 patient. Eight patients were converted to open surgery, and 2 received medical treatment. One patient suddenly died 2 hours after the primary stent grafting, and 2 died within 1 week after the surgical conversion, so mortality reached 27.3%. During the follow-up from 3 to 50 months, type I endoleak was identified in 1 patient 3 months after the surgical exploration and disappeared at 6 months. Retrograde type A aortic dissection after stent grafting for type B dissection appears not to be rare and results from mixed causes. Fragility of the aortic wall and disease progression may predispose to it, whereas stent grafting-related factors make important and provocative contributions. Avoiding aortic arch stent grafting in Marfan patients, preferably selecting the endograft without the proximal bare spring for patients with a kinked aortic arch or with Marfan syndrome (if endografting is used), improving the device design, and standardizing endovascular manipulation might lessen its occurrence.
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            The effect of left subclavian artery coverage on morbidity and mortality in patients undergoing endovascular thoracic aortic interventions: a systematic review and meta-analysis.

            Thoracic endografts (stent grafts) have emerged as a less invasive modality to treat various thoracic aortic lesions. The intentional coverage of the left subclavian artery (LSA) during the placement of these endografts is associated with several complications including stroke, spinal cord ischemia, and arm ischemia. In this review, we synthesize the available evidence regarding the complications associated with LSA coverage. We searched electronic databases (MEDLINE and EMBASE) from January 1990 through February 2008 for studies that included patients who received thoracic endografts and had intentional LSA coverage. Eligible studies had a control group that either received the endograft without LSA coverage or had primary revascularization prior to coverage. Two independent reviewers determined trial eligibility and extracted descriptive, methodological and outcome data from each eligible study. Meta-analyses estimated Peto odds ratio (OR) and 95% confidence intervals (CI) to describe the strength of association between coverage and complications; the I(2) statistic described the proportion of inconsistency of treatment effect among studies not due to chance. We found 51 eligible observational studies. LSA coverage was associated with significant increase in the risk of arm ischemia (OR 47.7; CI, 9.9-229.3; I(2) = 72%, 19 studies) and vertebrobasilar ischemia (OR 10.8; CI, 3.17-36.7; I(2) = 0%; eight studies); and nonsignificant increase in the risk of spinal cord ischemia (OR 2.69; CI, 0.75-9.68; I(2) = 40%; eight studies) and anterior circulation stroke (OR 2.58; CI, 0.82-8.09; I(2) = 64%, 13 studies). There were no significant associations between LSA coverage and death, myocardial infarction, or transient ischemic attacks. The incidence of phrenic nerve injury as a complication of primary revascularization was 4.40% (CI, 1.60%-12.20%). Data on perioperative infection were sparse and rarely reported. Very low quality evidence suggests that LSA coverage increases the risk of arm ischemia, vertebrobasilar ischemia, and possibly spinal cord ischemia and anterior circulation stroke.
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              The chimney graft: a technique for preserving or rescuing aortic branch vessels in stent-graft sealing zones.

              To report an alternative to the fenestrated stent-graft for preserving blood flow to side branches in the sealing zones of aortic stent-grafts. A covered stent is deployed parallel to the main aortic stent-graft, protruding somewhat proximally, like a chimney, to preserve flow to a vital side branch covered by the aortic stent-graft. Use of a chimney graft makes it possible to use standard off-the-shelf stent-grafts to instantly treat lesions with inadequate fixation zones, providing an alternative to fenestrated stent-grafts in urgent cases, in aneurysms with challenging neck morphology, and for reconstituting an aortic side branch unintentionally compromised during endovascular repair. This technique has been used successfully in 10 patients, combining chimney grafts in the renal, superior mesenteric, left subclavian, left common carotid, and innominate arteries with stent-grafts in the abdominal (n=6) or thoracic (n=4) aorta. There has been no late chimney graft-related endoleak on imaging studies up to 8 months. The use of chimney grafts is feasible in the renal and superior mesenteric arteries, as well as in the supra-aortic branches, to facilitate stent-graft repair of thoracic or abdominal aortic lesions with inadequate fixation zones.
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                Author and article information

                Journal
                J Thorac Dis
                J Thorac Dis
                JTD
                Journal of Thoracic Disease
                AME Publishing Company
                2072-1439
                2077-6624
                May 2020
                May 2020
                : 12
                : 5
                : 2270-2279
                Affiliations
                [1 ]Department of Vascular Surgery, Yan’an Affiliated Hospital of Kunming Medical University , Kunming 650051, China;
                [2 ]Key Laboratory of Cardiovascular Disease of Yunnan Province , Kunming 650051, China;
                [3 ]Yan’an Affiliated Hospital of Kunming Medical University , Kunming 650051, China
                Author notes

                Contributions: (I) Conception and design: J Zhang, X Liu; (II) Administrative support: H Chen, M Tian, J Tan; (III) Provision of study materials or patients: J Zhang, J Wang, M Ji; (IV) Collection and assembly of data: J Zhang, L Cong, E Zhu; (V) Data analysis and interpretation: J Zhang, X Liu; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

                [#]

                These authors contributed equally to this work.

                Correspondence to: Min Tian. Department of Vascular Surgery, Yan’an Affiliated Hospital of Kunming Medical University, Kunming 650051, China. Email: tm2002093@ 123456sina.com ; Jing Tan. Key Laboratory of Cardiovascular Disease of Yunnan Province, Kunming 650051, China. Email: kmtjing@ 123456sina.com .
                Article
                jtd-12-05-2270
                10.21037/jtd.2020.04.31
                7330391
                32642132
                7705d8c4-5607-4d84-99a7-a3db81f5aef0
                2020 Journal of Thoracic Disease. All rights reserved.

                Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

                History
                : 29 December 2019
                : 20 March 2020
                Categories
                Original Article

                thoracic endovascular repair,chimney graft/technique,looping,aortic aneurysm,aortic dissection

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