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      TAG (Tube and Graft) Sandwich Technique: A Novel Single-Stage Scleral Reinforcement and Aqueous Drainage Tube Implantation

      case-report
      1 , 2 , , 3 , 4
      Case Reports in Ophthalmological Medicine
      Hindawi

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          Abstract

          Purpose

          Refractory glaucoma patients continue to require surgical intervention in the form of trabeculectomy surgery or glaucoma drainage device (GDD). Those patients that require a GDD but have thin sclera or scleromalacia present a challenge.

          Methods

          In this article, we present a novel “TAG sandwich” single surgical procedure in which thinned sclera is reinforced with a pericardial patch graft (“bottom layer of the sandwich”) allowing safe implantation of the GDD (“the tube sandwich filling”) and then placing another patch graft on top of the tube part of the GDD (“top layer of the sandwich”). The surgery was performed on an open-angle glaucoma patient with a generalized thin sclera and uncontrolled intraocular pressure despite maximal topical medication and oral acetazolamide.

          Results

          Reinforcing a compromised sclera with a pericardium patch graft allowed the safe implantation of a glaucoma drainage device. The patient's intraocular pressure was safely controlled at 7 mmHg almost 1-year postsurgery without intraocular pressure-lowering drops.

          Conclusions

          This scleral strengthening procedure can be considered by readers in other ocular surgeries where there is a risk of scleral perforation, as well as part of a combined surgery where refractory glaucoma patients with thin sclera require scleral reinforcement to allow for safer implantation of a glaucoma drainage device.

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          Most cited references14

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          Treatment outcomes in the Tube Versus Trabeculectomy (TVT) study after five years of follow-up.

          To report 5-year treatment outcomes in the Tube Versus Trabeculectomy (TVT) Study. Multicenter randomized clinical trial. Seventeen clinical centers. Patients 18 to 85 years of age who had previous trabeculectomy and/or cataract extraction with intraocular lens implantation and uncontrolled glaucoma with intraocular pressure (IOP) ≥18 mm Hg and ≤40 mm Hg on maximum tolerated medical therapy. Tube shunt (350-mm(2) Baerveldt glaucoma implant) or trabeculectomy with mitomycin C ([MMC]; 0.4 mg/mL for 4 minutes). IOP, visual acuity, use of supplemental medical therapy, and failure (IOP >21 mm Hg or not reduced by 20%, IOP ≤5 mm Hg, reoperation for glaucoma, or loss of light perception vision). A total of 212 eyes of 212 patients were enrolled, including 107 in the tube group and 105 in the trabeculectomy group. At 5 years, IOP (mean ± SD) was 14.4 ± 6.9 mm Hg in the tube group and 12.6 ± 5.9 mm Hg in the trabeculectomy group (P = .12). The number of glaucoma medications (mean ± SD) was 1.4 ± 1.3 in the tube group and 1.2 ± 1.5 in the trabeculectomy group (P = .23). The cumulative probability of failure during 5 years of follow-up was 29.8% in the tube group and 46.9% in the trabeculectomy group (P = .002; hazard ratio = 2.15; 95% confidence interval = 1.30 to 3.56). The rate of reoperation for glaucoma was 9% in the tube group and 29% in the trabeculectomy group (P = .025). Tube shunt surgery had a higher success rate compared to trabeculectomy with MMC during 5 years of follow-up in the TVT Study. Both procedures were associated with similar IOP reduction and use of supplemental medical therapy at 5 years. Additional glaucoma surgery was needed more frequently after trabeculectomy with MMC than tube shunt placement. Copyright © 2012 Elsevier Inc. All rights reserved.
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            Use of Various Glaucoma Surgeries and Procedures in Medicare Beneficiaries from 1994 to 2012.

            Determine how procedural treatments for glaucoma have changed between 1994-2012.
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              Ehlers-Danlos syndrome type VI: clinical manifestations of collagen lysyl hydroxylase deficiency.

              We reviewed the clinical findings in 10 patients with lysyl hydroxylase deficiency (Ehlers-Danlos syndrome type VI) and report here the range of clinical severity in these patients. The distinctive feature common to all patients was muscle hypotonia with joint laxity in the newborn period, and moderate to severe kyphoscoliosis either was present or developed in almost all patients. Most patients also had some degree of skin abnormality observed in other types of Ehlers-Danlos syndrome: bruisability, abnormal scarring, and soft, distensible skin. These patients also are at risk for potentially catastrophic arterial rupture.
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                Author and article information

                Contributors
                Journal
                Case Rep Ophthalmol Med
                Case Rep Ophthalmol Med
                CRIOPM
                Case Reports in Ophthalmological Medicine
                Hindawi
                2090-6722
                2090-6730
                2021
                14 July 2021
                : 2021
                : 6698919
                Affiliations
                1The Western Eye Hospital, Imperial College Healthcare NHS Trust, 153-173 Marylebone Rd, London, UK
                2The Imperial College Ophthalmic Research Group (ICORG), Imperial College London, 153-173 Marylebone Rd, London, UK
                3The Ophthalmology Department, Faculty of Medicine, Alexandria University, Champollion Street, Alexandria, Egypt
                4Whipps Cross Hospital, Barts Health NHS Trust, Whipps Cross Rd, Leytonstone, London, UK
                Author notes

                Academic Editor: Hsin Yi Chen

                Author information
                https://orcid.org/0000-0003-0015-6008
                https://orcid.org/0000-0001-5448-3659
                Article
                10.1155/2021/6698919
                8294996
                34336324
                77c3c348-7d69-48b8-988e-7610c29cdf47
                Copyright © 2021 Faisal Ahmed and Nada G. Mohamed.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 15 December 2020
                : 31 March 2021
                : 16 April 2021
                Categories
                Case Report

                Ophthalmology & Optometry
                Ophthalmology & Optometry

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