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      Factors Influencing Measurement of Serum Iron Concentration in Dogs: Diurnal Variation and Hyperferritinemia

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          ABSTRACT

          We evaluated diurnal variation and hyperferritinemia as factors that influence the values of serum iron concentration in dogs, using the International Committee for Standardization in Hematology (ICSH) colorimetric method. Serum iron levels were significantly higher in the morning than in the evening in 6 clinically healthy beagle dogs, and the maximum decrease in serum iron concentration was 47.3%. Moreover, the change in serum iron concentrations in 22 clinical canine cases with various serum ferritin levels was evaluated by immunoprecipitation of ferritin. The rate of decline in the serum iron concentrations positively correlated with serum ferritin levels (r=0.48, P=0.024). These results show that it is necessary to consider the sampling time and serum ferritin level for accurate interpretation of serum iron concentrations in dogs.

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          Ferrozine---a new spectrophotometric reagent for iron

          Lawrence Stookey (2002)
          Article 0 comments Cited 620 times – based on 0 reviews     Review now
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            Immunoassay for human serum hepcidin.

            Elizabeta Nemeth, Gordana Olbina, G Olbina … (2008)
            We developed and validated the first serum enzyme-linked immunosorbent assay for hepcidin, the principal iron-regulatory hormone that has been very difficult to measure. In healthy volunteers, the 5% to 95% range of hepcidin concentrations was 29 to 254 ng/mL in men (n = 65) and 17 to 286 ng/mL in women (n = 49), with median concentrations 112 versus 65 (P 10 mg/dL), multiple myeloma, or chronic kidney disease. The new serum hepcidin enzyme-linked immunosorbent assay yields accurate and reproducible measurements that appropriately reflect physiologic, pathologic, and genetic influences, and is informative about the etiology of iron disorders.
            Article 0 comments Cited 130 times – based on 0 reviews     Review now
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              Diurnal variation of serum iron, iron-binding capacity, transferrin saturation, and ferritin levels.

              Alan R Zinsmeister, Russell Dale, M F Burritt (2002)
              Serum iron levels vary throughout the day. Morning levels are generally assumed to be higher than afternoon or evening levels. We studied whether our practice of restricting serum iron collections to the morning was necessary. Serum iron, iron-binding capacity, transferrin saturation, and ferritin levels were determined on blood specimens obtained from 20 healthy adult volunteers at 8 AM, noon, and 4 PM (day 1) and 8 AM (day 2). Although statistically significant differences among mean values for the collection times were observed for iron, iron-binding capacity, and (log) ferritin, no consistent diurnal variation was seen. Morning iron levels were higher than afternoon levels for only half of the subjects. Between-day variation for all 4 analytes was similar to within-day variation. We conclude that the practice of restricting iron specimen collections to a specific time of day does not improve the reliability of the test result.
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                Author and article information

                Journal
                Journal ID (nlm-ta): J Vet Med Sci
                Journal ID (iso-abbrev): J. Vet. Med. Sci
                Journal ID (publisher-id): JVMS
                Title: The Journal of Veterinary Medical Science
                Publisher: The Japanese Society of Veterinary Science
                ISSN (Print): 0916-7250
                ISSN (Electronic): 1347-7439
                Publication date (Electronic): 23 July 2013
                Publication date (Print): December 2013
                Volume: 75
                Issue: 12
                Pages: 1615-1618
                Affiliations
                [1) ]Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University, 23–35–1 Higashi, Towada, Aomori 034–8628, Japan
                [2) ]Laboratory of Biochemistry, School of Veterinary Medicine, Kitasato University, 23–35–1 Higashi, Towada, Aomori 034–8628, Japan
                Author notes
                [* ]Correspondence to: Chikazawa, S., Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University, 23–35–1 Higashi, Towada, Aomori 034–8628, Japan. e-mail: chikazaw@ 123456vmas.kitasato-u.ac.jp
                Article
                Publisher ID: 13-0286
                DOI: 10.1292/jvms.13-0286
                PMC ID: 3942948
                PubMed ID: 23877842
                SO-VID: 77d65bb3-f570-41fe-b17a-1f269dfff462
                Copyright © ©2013 The Japanese Society of Veterinary Science
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.

                History
                Date received : 04 June 2013
                Date accepted : 09 July 2013
                Categories
                Subject: Note
                Subject: Clinical Pathology

                Keywords: canine,diurnal variation,ferritin,serum iron
                Data availability:
                Keywords: canine, diurnal variation, ferritin, serum iron

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