Interleukin 35 Expression Correlates With Microvessel Density in Pancreatic Ductal Adenocarcinoma, Recruits Monocytes, and Promotes Growth and Angiogenesis of Xenograft Tumors in Mice.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Cells of the monocyte lineage contribute to tumor angiogenesis. Interleukin 35 (IL35) is a member of the IL12 family produced by regulatory, but not effector, T cells. IL35 is a dimer comprising the IL12 alpha and IL27 beta chains, encoded by IL12A and EBI3, respectively. Expression of IL35 is increased in pancreatic ductal adenocarcinomas (PDACs) compared with normal pancreatic tissues, and promotes metastasis. We investigated the role of IL35 in monocyte-induced angiogenesis of PDAC in mice.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Gastroenterology

Title: Gastroenterology

Publisher: Elsevier BV

ISSN (Electronic): 1528-0012

ISSN (Print): 0016-5085

Publication date (Electronic): February 2018

Volume: 154

Issue: 3

Affiliations

[1 ] Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China; Senior Ward, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.

[2 ] Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.

[3 ] School of Medicine, Nankai University, Tianjin 300071, China.

[4 ] Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania 17033.

[5 ] Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China. Electronic address: haojihui@tjmuch.com.

[6 ] Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China. Electronic address: renhe@tjmuch.com.

Article

Publisher Item ID: S0016-5085(17)36198-X

DOI: 10.1053/j.gastro.2017.09.039

PubMed ID: 28989066

SO-VID: 786baad6-c6c6-4f11-bec0-2c4acfd6859b

History

Keywords: Infiltration,Tumor Progression,Immune Cell Migration,Anti-tumor Immune Response

Data availability:

Keywords: Infiltration, Tumor Progression, Immune Cell Migration, Anti-tumor Immune Response

Interleukin 35 Expression Correlates With Microvessel Density in Pancreatic Ductal Adenocarcinoma, Recruits Monocytes, and Promotes Growth and Angiogenesis of Xenograft Tumors in Mice.

Read this article at

Abstract

Related collections

Karger: Gastroenterology

Author and article information

Journal

Affiliations

Article

History

Comments

Comment on this article

Similar content 121

Cited by 50