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      Spontaneous Corpus Cavernosum Abscess in a Healthy Man Using Long-Term Androgenic Anabolic Steroids

      case-report

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          Abstract

          Abscess formation of the corpus cavernosum is very rare. Here, we report a case of long-term anabolic androgenic steroid (AAS) abuse that is suspected to have facilitated the development of a corpus cavernosum abscess in a healthy bodybuilder. Cultures obtained from the abscess contained Staphylococcus epidermidis, a microorganism that almost exclusively affects immunocompromised patients. Therefore, prompt drainage of pus from cavernosal bodies should be the primary aim of the treatment. This case illustrates the potential danger of AAS suppressing the immune system and causing a serious infection.

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          Cavernosal Abscess due to Streptococcus Anginosus: A Case Report and Comprehensive Review of the Literature

          Caitlin Dugdale, Andrew J. Tompkins, Rebecca Reece … (2013)
          Corpus cavernosum abscesses are uncommon with only 23 prior reports in the literature. Several precipitating factors for cavernosal infections have been described including injection therapy for erectile dysfunction, trauma, and priapism. Common causal organisms include Staphylococcus aureus, Streptococci, and Bacteroides. We report a unique case of a corpus cavernosum abscess due to proctitis with hematological seeding and review the literature on cavernosal abscesses.
          Article 0 comments Cited 15 times – based on 0 reviews     Review now
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            Androgenic anabolic steroid use and severe hypothalamic-pituitary dysfunction: a case study.

            Bruce H. R. Wolffenbuttel, H. Jan Keizer, Peter van Lent … (2003)
            The data of the present case demonstrate that the abuse of androgenic anabolic steroids (AAS) may lead to serious health effects. Although most clinical attention is usually directed towards peripheral side effects, the most serious central side effect, hypothalamic-pituitary-dysfunction, is often overlooked in severe cases. Although this latter central side-effect usually recovers spontaneously when AAS intake is discontinued, the present case shows that spontaneous recovery does not always take place. We suggest that hypothalamic-pituitary dysfunction should always be considered in the differential diagnosis in athletes seen with typical presentation of anabolic steroid use. In order to regain normal hypothalamic-pituitary function, supraphysiological doses of 200 microg LH-RH should be considered when the physiological challenge test with LH-RH (50 microg) fails to show an acceptable response.
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              The effects of anabolic steroids and strength training on the human immune response.

              L H Calabrese, S Kleiner, B Barna … (1989)
              The immune response was assessed in 13 competitive bodybuilders self-administering anabolic-androgenic steroids and ten competitive bodybuilders not administering these drugs. Laboratory assessment included the number and relative distribution of T-cells, T-helper/inducer cells, T-cytotoxic/suppressor cells, activated T-cells, lymphocyte transformation to the mitogens, pokeweed mitogen (PWM), phytohemagglutinin (PHA), Concanavalin-A (CON-A), Staphylococcus aureus Cowan strain I (SAC), serum immunoglobulins, and natural killer (NK) activity. There were no significant differences in T-cell subsets among steroid users and non-users, but lymphocyte transformation studies revealed that the anabolic-androgenic steroid-using group had enhanced proliferative ability to the B-cell mitogen, SAC, in comparison to non-bodybuilding controls. NK activity was significantly (P less than 0.05) augmented in the anabolic-androgenic steroid users but not in the non-using bodybuilders. Serum immunoglobulin levels, in particular IgA, were significantly (P less than 0.017) lower in the steroid-using group. Four of 13 steroid users and three of eight non-steroid-using bodybuilders had detectable antinuclear antibodies. These studies indicate that 1) anabolic-androgenic steroid use as practiced by contemporary athletes is a potent modulator of immune responsiveness and 2) autoantibodies are prevalent in strength-trained men even in the absence of anabolic steroid use.
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                Author and article information

                Journal
                Journal ID (nlm-ta): World J Mens Health
                Journal ID (iso-abbrev): World J Mens Health
                Journal ID (publisher-id): WJMH
                Title: The World Journal of Men's Health
                Publisher: Korean Society for Sexual Medicine and Andrology
                ISSN (Print): 2287-4208
                ISSN (Electronic): 2287-4690
                Publication date (Print): April 2015
                Publication date (Electronic): 23 April 2015
                Volume: 33
                Issue: 1
                Pages: 36-38
                Affiliations
                Department of Urology, Baskent University Zübeyde Hanim Practice and Research Center, Izmir, Turkey.
                Author notes
                Correspondence to: Emre Tü zel. Department of Urology, Baskent University Zü beyde Hanim Practice and Research Center, Cahar Dudayev Bul. No. 3 Karya Evleri B Blok R Giriş Kat 3 Da, 8, Istasyonalti Cigli 35630 Izmir, Turkey. Tel: +90-532-456-20-88, Fax: +90-232-336-48-49, emretuzel@ 123456gmail.com
                Article
                DOI: 10.5534/wjmh.2015.33.1.36
                PMC ID: 4412006
                PubMed ID: 25927061
                SO-VID: 78f68bbd-750b-48bb-9de6-994f95ef6ad4
                Copyright © Copyright © 2015 Korean Society for Sexual Medicine and Andrology
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 29 September 2014
                Date revision received : 20 October 2014
                Date accepted : 25 October 2014
                Categories
                Subject: Case Report

                Keywords: abscess,anabolic agents,infection,staphylococcus epidermidis
                Data availability:
                Keywords: abscess, anabolic agents, infection, staphylococcus epidermidis

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