T1-/T2-weighted ratio differs in demyelinated cortex in multiple sclerosis.

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Abstract

Detecting cortical demyelination in patients with multiple sclerosis (MS) is difficult. Using magnetic resonance imaging (MRI), ratio maps of T1-weighted (T1w) and T2-weighted (T2w) images may be sensitive to cortical myelin levels. In this MRI-histological study, postmortem in situ scans were acquired from 6 cadavers with MS on a 3T MRI machine. Immunocytochemistry was used to correlate myelin status and cortical T1w/T2w measures. The results showed that the T1w/T2w values significantly differed between demyelinated and myelinated cortex (p < 0.001). The T1w/T2w ratio maps may be a relatively simple, clinically feasible method to assess cortical demyelination. Ann Neurol 2017;82:635-639.

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Journal

Journal ID (iso-abbrev): Ann. Neurol.

Title: Annals of neurology

Publisher: Wiley

ISSN (Electronic): 1531-8249

ISSN (Print): 0364-5134

Publication date (Electronic): Oct 2017

Volume: 82

Issue: 4

Affiliations

[1 ] Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic.

[2 ] Department of Neuroscience, Lerner Research Institute, Cleveland Clinic.

[3 ] Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, Cleveland, OH.

Article

DOI: 10.1002/ana.25019

PubMed ID: 28833377

SO-VID: 7a089d50-66ac-4c56-a7d1-11d80fc1a885

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