Javier Morales-Ramirez: Role: InvestigationRole: Resources
Johannes R. Bogner: Role: InvestigationRole: Resources
Jean-Michel Molina: Role: InvestigationRole: Resources
Johan Lombaard: Role: InvestigationRole: Resources
Ira B. Dicker: Role: Formal analysis
David A. Stock: Role: Formal analysis
Michelle DeGrosky: Role: Formal analysis
Margaret Gartland: Role: Formal analysis
Teodora Pene Dumitrescu: Role: Formal analysis
Sherene Min: Role: Formal analysis
Cyril Llamoso: Role: Formal analysis
Samit R. Joshi: Role: Formal analysisRole: Project administration
Max Lataillade:
ORCID: http://orcid.org/0000-0001-6103-8967
Role: Formal analysis
Giuseppe Vittorio De Socio: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
23
October
2018
Publication date Collection: 2018
Volume: 13
Issue: 10
Electronic Location Identifier: e0205368
Affiliations
[1
]
Clinical Research Puerto Rico Inc., San Juan, Puerto Rico
[2
]
Med IV, Hospital of the University of Munich, Munich, Germany
[3
]
Hôpital St Louis, Paris, France
[4
]
Josha Research, Bloemfontein, South Africa
[5
]
ViiV Healthcare, Branford, Connecticut, United States of America
[6
]
Bristol-Myers Squibb, Wallingford, Connecticut, United States of America
[7
]
ViiV Healthcare, Research Triangle Park, North Carolina, United States of America
[8
]
GlaxoSmithKline, Upper Merion, Pennsylvania, United States of America
Azienda Ospedaliera Universitaria di Perugia, ITALY
Author notes
Competing Interests: I have read the journal’s policy and the authors of this manuscript have the following
competing interests: IBD, CL, SRJ, SM and MD are employees of ViiV Healthcare, ML
and MG are employees of ViiV Healthcare and shareholders at GlaxoSmithKline. TPD is
an employee of GlaxoSmithKline, J-MM reports advisory boards for Gilead, Merck, ViiV
Healthcare, Bristol-Myers Squibb (BMS), Janssen and Teva and grants from Gilead, JM-R
reports no conflict of interest, JRB reports personal fees from BMS, ViiV Healthcare,
Merck Sharpe and Dohme, Gilead, Janssen and Hexal, DAS was an employee of Bristol-Myers
Squibb during conduct of the study. JM-R and JL have no conflicts to declare. This
does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.
Author information
Article
Publisher ID:
PONE-D-18-11417
DOI: 10.1371/journal.pone.0205368
PMC ID: 6198970
PubMed ID: 30352054
SO-VID: 7a17e35c-b191-4f5f-bd45-1c94fd6ad6d0
Copyright © © 2018 Morales-Ramirez et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funding was provided by Bristol-Myers Squibb, original sponsor (and through the Week
24 analysis) of 205891. ViiV Healthcare UK Limited subsequently acquired the GSK3532795
compound and now supports the study.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Microbial Control
Subject:
Antimicrobial Resistance
Subject:
Medicine and Health Sciences
Subject:
Pharmacology
Subject:
Antimicrobial Resistance
Subject:
Medicine and Health Sciences
Subject:
Gastroenterology and Hepatology
Subject:
Diarrhea
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Signs and Symptoms
Subject:
Diarrhea
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Signs and Symptoms
Subject:
Diarrhea
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Research and Analysis Methods
Subject:
Research Design
Subject:
Clinical Research Design
Subject:
Adverse Events
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Medicine and Health Sciences
Subject:
Pharmaceutics
Subject:
Dose Prediction Methods
Subject:
Adjustment of Dosage at Steady State
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Enzymology
Subject:
Enzymes
Subject:
Transferases
Subject:
Aminotransferases
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Enzymes
Subject:
Transferases
Subject:
Aminotransferases
