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Phase III Multi-Center, Prospective, Randomized Trial Comparing Single Dose 24 Gy Radiotherapy to a 3-Fraction SBRT Regimen in the Treatment of Oligometastatic Cancer
Michael J. Zelefsky ,
Yoshiya Yamada ,
Carlo Greco ,
Eric Lis ,
Heiko Schöder ,
Stephanie Lobaugh ,
Zhigang Zhang ,
Richard Braunstein ,
Mark H. Bilsky ,
Simon N. Powell ,
Richard Kolesnick ,
Zvi Fuks
January 2021
January 2021
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Abstract
<p class="first" id="d8956797e208">This prospective phase 3 randomized trial was designed
to test whether ultra high
single-dose radiation therapy (24 Gy SDRT) improves local control of oligometastatic
lesions compared to a standard hypofractionated stereotactic body radiation therapy
regimen (3 × 9 Gy SBRT). The secondary endpoint was to assess the associated toxicity
and the impact of ablation on clinical patterns of metastatic progression.
</p>