Sophia D. Lin: Role: Data curationRole: Formal analysisRole: InvestigationRole: Writing – original
draft
Jane E. Butler: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
Project administrationRole: SupervisionRole: ValidationRole: Writing – review & editing
Claire L. Boswell-Ruys: Role: Data curationRole: InvestigationRole: Project administrationRole: SupervisionRole:
ValidationRole: Writing – review & editing
Phu Hoang: Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Project administrationRole:
ResourcesRole: SupervisionRole: ValidationRole: Writing – review & editing
Tom Jarvis: Role: Project administrationRole: ResourcesRole: SupervisionRole: ValidationRole:
Writing – review & editing
Simon C. Gandevia: Role: Project administrationRole: ResourcesRole: SupervisionRole: ValidationRole:
Writing – review & editing
Euan J. McCaughey:
ORCID: http://orcid.org/0000-0001-6596-110X
Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole:
MethodologyRole: Project administrationRole: ResourcesRole: SoftwareRole: SupervisionRole:
ValidationRole: Writing – review & editing
Jessica Louise Fletcher: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
19
September
2019
Publication date Collection: 2019
Volume: 14
Issue: 9
Electronic Location Identifier: e0222731
Affiliations
[1
]
Neuroscience Research Australia, Randwick, NSW, Australia
[2
]
School of Medical Sciences, University of New South Wales, Kensington, NSW, Australia
[3
]
Continence Clinic, MS Limited, Sydney, Australia
[4
]
Australian Catholic University, Sydney, Australia
[5
]
Prince of Wales Clinical School, University of New South Wales Medicine, University
of New South Wales, Sydney, NSW, Australia
University of Melbourne, AUSTRALIA
Author notes
Competing Interests: PH and TJ are employees of MS Limited. This does not alter our adherence to PLOS ONE
policies on sharing data and materials.
Author information
Article
Publisher ID:
PONE-D-19-15442
DOI: 10.1371/journal.pone.0222731
PMC ID: 6752850
PubMed ID: 31536557
SO-VID: 7ae617e2-61ae-4c63-8e05-0ce8f376024c
Copyright © © 2019 Lin et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/100000890, National Multiple Sclerosis Society;
Award ID: PP-1804-30637
Award Recipient
:
Simon C. Gandevia
Funded by: funder-id http://dx.doi.org/10.13039/501100000925, National Health and Medical Research Council;
Award ID: APP1122932
Award Recipient
:
ORCID: http://orcid.org/0000-0001-6596-110X
Euan J. McCaughey
This work was supported by a pilot grant from the National Multiple Sclerosis Society
(NMSS), USA and the National Health and Medical Research Council (NHMRC), Australia.PH
and TJ are employed by MS Limited. MS Limited provided support in the form of salaries
for PH and TJ, but did not have any additional role in the study design, data collection
and analysis, decision to publish, or preparation of the manuscript. The specific
roles of these authors are articulated in the ‘author contributions’ section.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Renal System
Subject:
Bladder
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Renal System
Subject:
Bladder
Subject:
Medicine and Health Sciences
Subject:
Clinical Medicine
Subject:
Clinical Immunology
Subject:
Autoimmune Diseases
Subject:
Multiple Sclerosis
Subject:
Biology and Life Sciences
Subject:
Immunology
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Clinical Immunology
Subject:
Autoimmune Diseases
Subject:
Multiple Sclerosis
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Medicine and Health Sciences
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Immunology
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Clinical Immunology
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Autoimmune Diseases
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Multiple Sclerosis
Subject:
Medicine and Health Sciences
Subject:
Neurology
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Demyelinating Disorders
Subject:
Multiple Sclerosis
Subject:
Medicine and Health Sciences
Subject:
Neurology
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Neurodegenerative Diseases
Subject:
Multiple Sclerosis
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
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Signs and Symptoms
Subject:
Fatigue
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Medicine and Health Sciences
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Pathology and Laboratory Medicine
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Signs and Symptoms
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Fatigue
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Medicine and Health Sciences
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Urology
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Incontinence
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Medicine and Health Sciences
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Gastroenterology and Hepatology
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Constipation
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Medicine and Health Sciences
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Diagnostic Medicine
Subject:
Signs and Symptoms
Subject:
Constipation
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Signs and Symptoms
Subject:
Constipation
Subject:
People and Places
Subject:
Geographical Locations
Subject:
Oceania
Subject:
Australia
Subject:
Computer and Information Sciences
Subject:
Graph Theory
Subject:
Directed Graphs
Subject:
Directed Acyclic Graphs
Subject:
Physical Sciences
Subject:
Mathematics
Subject:
Graph Theory
Subject:
Directed Graphs
Subject:
Directed Acyclic Graphs
Subject:
Research and Analysis Methods
Subject:
Mathematical and Statistical Techniques
Subject:
Statistical Methods
Subject:
Regression Analysis
Subject:
Linear Regression Analysis
Subject:
Physical Sciences
Subject:
Mathematics
Subject:
Statistics
Subject:
Statistical Methods
Subject:
Regression Analysis
Subject:
Linear Regression Analysis
