INTRODUCTION
Before the development of acute hemodialysis, mortality rate of acute renal failure
(ARF) approached 100% in World War II.[1] Most of these kidney injuries were caused
by crush injuries as described by Bywaters and Beall. The use of hemodialysis was
first described in military services during the Korean War in 1950 for renal military
casualties; this has led to a decline in mortality rate from around 90% to 53%.[2
3] Early intervention could prevent the occurrence of ARF, at least in military casualties.[4]
During disasters and War situations, the delivery of healthcare services including
hemodialysis can be interrupted due to destruction of medical facilities and infrastructure,
lack of healthcare personnel, shortage of equipment and supplies, and interruption
of electricity and water. The conduction of hemodialysis can also be interrupted by
technical or electrical issues such as electrical power blackouts.[5]
The uprising demand for political change in Syria that started from March 2011 has
marked the beginning of an ongoing Syrian political and humanitarian crisis. This
conflict has led to a significant decline of living standards, loss of healthcare
facilities, flight of medical personnel, severe shortage of medicines, lack of essential
supplies and an increased risk of infectious diseases in the affected areas. According
to the World Health Organization (WHO), the crisis context has compromised the provision
of primary and secondary healthcare, the referral of injured patients, treatment of
chronic diseases, disruption of maternal and child health services, vaccination and
nutritional programs and that of communicable disease control.[6]
Renal care and hemodialysis patients were not the exception. The complexity and the
requirements of the hemodialysis procedure magnified the problem in delivering quality,
effective and safe services. All or some components of renal care were inadequate
or completely absent due to security issues, unavailability of supplies, interruption
of water and electricity, absence of maintenance and support, and absence of equipment
and essential materials. Accurate figures are lacking due to scarce and limited data
from the area and most of the information is based on direct observation and rare
reports.
Many medical relief efforts were organized by non-governmental organizations (NGOs),
including the Syrian American Medical Society (SAMS), to provide medical and psychological
support to the internally displaced people, people in conflict-affected areas and
Syrian refugees in surrounding countries.[7] Among the different medical missions
of Syria, SAMS was the mission of the Syrian American Nephrologists to refugee camps
and Northern Syria with the objective of providing a preliminary assessment of the
care delivery status of renal patients. Their direct observation revealed that the
care of dialysis patients was severely compromised due to lack of access to dialysis
units, electricity outage, lack of medications and equipment, destruction of healthcare
facilities and shortage of medical care providers. The majority of dialysis facilities
had no supervising nephrologists; some of the provinces lacked the existence of any
nephrologist. The majority of ARF was caused by crush injuries and rhabdomyolysis
(54%) followed by gunshot injury (35%) per the observation of one of SAMS physicians
who visited northern Syria. Mortality figures were not available due to destruction
of information system and lack of any data collection, many deaths occurred in fields
due to massive hemorrhage, crush injuries and the lack of appropriate resuscitation.
Victims who survived the initial shock have developed ARF-acute kidney injury (AKI)
and most of them died because of complications of ARF-AKI since renal replacement
therapy (RRT) was not available. Some renal transplant patients had rejection and
ended up on dialysis because of inability to find or afford anti-rejection medications.
Renal disease and renal care in Syria
There is not enough data in the medical literature regarding the status of renal care
in Syria before or after the crisis. We do not know the true incidence of end stage
renal disease (ESRD) due to lack of national registry. WHO website did not publish
any data or statistics in regard to renal care in Syria. A Medline search revealed
one article published in 2009 entitled “Epidemiology of Hemodialysis Patients in Aleppo
City” where it was reported that a total of 550 dialysis patients existed in the city
of Aleppo.[8] In May 2005, the annual report of renal replacement therapy (RRT) in
Syria, which was issued by department of the ministry of health, revealed that there
were 2750 new patients on hemodialysis (HD) and 111 patients on continuous ambulatory
peritoneal dialysis (CAPD).[9] In an estimate, from a physician who used to work at
the Syrian Department of Health and now collaborates with SNKF, the total number of
dialysis patients before the war started was about 7000.
Renal and dialysis patients would have been the most vulnerable people among all chronic
diseases during the conflict and their care would have been affected majorly due to
their fragile status, co-morbidities and the complexity of offered treatments.
There are numerous anecdotal reports by SNKF members indicating the major impact of
the crisis on the functionality of hemodialysis units and dialysis machines. For example,
in one observation of a hemodialysis center in Aleppo; the electricity was available
through a diesel-run generator with 3-4 shifts per day for six days with Friday being
only for emergencies and is the only day-off for the technicians. There was one machine
for hepatitis B isolation; and the center tried to make a “hepatitis B shift” as much
as possible. Fistulas and temporary subclavian catheters were the main vascular access.
There was no interventional care for maturation or maintenance of the fistulas and
the catheters are kept for very long duration (sometimes 2-3 years). No tunneled catheters
were used due to cost and no grafts due to cost and lack of surgical experience with
implantation. The concepts of venous vascular balloons, stents, or decloting did not
exist. Cannulation of those fistulas was sometimes challenging but the technician
has adapted very well to the procedure. Temporary subclavian catheters are commonly
used. The rate of line infections was probably underappreciated and usually treated
with empiric antibiotics without replacement or exchange. The lines were not placed
under ultrasonographic guidance. The standard of care regarding the frequency of dialysis
was one per week and sometimes two but very rarely to have dialysis schedule of three
times a week except if the patients were financially secure. Many patients did not
understand the concept of chronic hemodialysis and the ongoing need for that. This
was especially true for new starts. Dialysis baths were usually 2K (2 meq/L) premade
without any other option for other concentrations for the acid. The base was made
from powder and was quite cheap and available. The facility also accepted all non-critical
patients including primary care both adults and pediatrics. Critically ill patients
were transported to bigger centers after stabilization. The facility was shared with
ophthalmology, wound and burn care. It had minimal security and no internet connection.
The SNKF team concluded that lack of physician support is a major cause of less than
the optimal delivered renal care. However, the current staff was doing a great job
compared to the resources they have, whether that be in- personnel, knowledge or equipment.
Physician support and supervision could be re-established if the facility gets a satellite
internet connection.
Syrian national kidney foundation
The Syrian National Kidney Foundation (SNKF) idea was established by two Syrian American
nephrologists in San Diego during the American Society of Nephrology (ASN) Renal Week
in November 2012.
Initially, the mission was to deliver care to the Syrian renal patients in need. Overtime,
it was refined to:
Facilitate, support, and deliver care to the renal and dialysis patients in Syria
through collaboration with different organizations.
Support staff and providers with objective of prioritizing needs and maximizing benefits
despite limited resources.
Standardize the nephrology practice and improve outcome of renal patients in Syria.
The vision is to become the foundation of kidney diseases in Syria for all nephrologists.
The objective is to have a structured approach towards improving delivery and quality
of care for dialysis, renal transplant and AKI patients. The group consists of nephrologists,
biomedical engineers, dialysis technicians, administrators, and Syrian internists
involved in the care of kidney patients. The group meets weekly via Skype. The core
functions of the group are shown in Table 1.
Table 1
The core functions of the SNKF
The first official meeting was in February 2013 during the national conference of
the SAMS held in Tampa, Florida. A detailed report from a returned physician from
Syria confirmed the complete lack of nephrologists in some areas and the shutdown
of many hemodialysis units in other areas. In neighboring countries such as Lebanon
and Turkey, patients were receiving hemodialysis with different standards and supported
form different charity organizations. There were at least 30 hemodialysis patients
in northern Lebanon with lack of essential medicines including erythropoiesis-stimulating
agents. The plan was to raise funds from the foundation members and through different
channels for a purchase of dialysis machine. They also worked on conducting the first
in-service for local physicians, nurses and technicians by maintaining communication
and follow-up through regular telecommunication and Skype.
A follow-up meeting was held in Atlanta on March 24, 2013 where discussion took place
on what has been accomplished and on the need of the establishment of a complete dialysis
unit with a stable budget to operate and maintain. More roles that are active among
the nephrologists took place to increase awareness about the foundation. Personal
contacts and emails were used and channels in social media such as Facebook and YouTube
were opened.[10
11] This led to an increased recruitment of nephrologists from around the world into
the foundation, with a total number reaching 35, and increased missions to Syria and
refugee camps. A weekly renal transplant clinic was started with the support of internist
staff providing support via internet by a US transplant nephrologist. More financial
support has led to the establishment of the dialysis unit in Idlib, operate it and
maintain it with supplies, medications along with a continued education and support
from nephrologists. The facility is located in rural Idlib, using 2 hemodialysis machines
and supports 18 ESRD patients.
Novel and cost effective ideas helped providing new solutions for RRT in the intensive
care unit (ICU) for AKIpatients. An Improvized setup for continuous veno-venous hemofiltration
(CVVH) was developed, standardized, tested and successfully implemented. It was simplified
to be used in harsh conditions, like using a car battery as an electrical source.
[Figure 1] Staff training was simple, hands on and YouTube videos were produced,[11]
as well as protocols were developed taking into consideration the available local
resources. Remote real time Skype support was available as well. By the time this
paper is written, 6 patients were saved using this method. The SNKF physicians are
in the process of writing a case series describing this accomplishment and will be
submitted to a peer review journal. A summary of SNKF accomplishments so far is shown
in Table 2.
Figure 1
CVVH using a stand-alone blood pump for ARF in field hospitals in Syria. A car battery
used as source of electricity
Table 2
Some SNKF accomplishments
While trying to provide safe treatment, the war may require that the nephrologist
set aside his or her standard approaches and guidelines and seek innovative ways in
order to maximize outcomes for the greatest number of individuals using limited recourses.[12]
SNKF progressed from a group of doctors working individually to a legitimate and organized
body working on a comprehensive project to improve health care in general and dialysis
patients particularly in Syria at time of war and in the future peace. The work of
SNKF will add to our current knowledge about renal care in disaster situations. The
knowledge currently stems mostly from lessons learned while taking care of crush syndrome
patients and during major earthquakes.[13]
The foundation is still in the establishment phase and growing steadily as planned,
but much more is needed to accomplish its mission and the foundation members agreed
to proceed based on the following approach:
Strengthen the organizational structure of the foundation and establish key offices
including a quality assurance, human resource and operation coordinator offices
Build a sustainable capacity of the foundation through direct interaction and collaboration
with different regional and international organizations
Expand aid responses by developing a strategy that addresses renal care in other areas
such as Turkey and Lebanon and develop an emergency preparedness plan for AKI and
CKD patients in these areas
Increase the awareness of public as well as physicians to the foundation through different
media promotion and advertisement programs
Establish an operation budget, secure sources for income, establish mechanisms to
ensure accountability and enhance donations and volunteerism.
CONCLUSION
Teamwork between Syrian American Nephrologists, other nephrologists from around the
world, technicians, engineers, and Syrian physicians has translated into a reasonably
safe and effective treatment for Syrian renal patients in this dire situation. The
SNKF will continue to progress, to achieve its objectives in developing an emergency
preparedness plan for AKI and CKD patients and improving outcome of those patients.
The structure, approach and experience of the SNKF could be a guide to other Syrian
and non-Syrian provider groups involved in healthcare delivery in disastrous situations.
More studies on the care of renal casualties during crisis in resource-limited counties
are desperately needed.