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      Deep learning for detecting retinal detachment and discerning macular status using ultra-widefield fundus images

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          Abstract

          Retinal detachment can lead to severe visual loss if not treated timely. The early diagnosis of retinal detachment can improve the rate of successful reattachment and the visual results, especially before macular involvement. Manual retinal detachment screening is time-consuming and labour-intensive, which is difficult for large-scale clinical applications. In this study, we developed a cascaded deep learning system based on the ultra-widefield fundus images for automated retinal detachment detection and macula-on/off retinal detachment discerning. The performance of this system is reliable and comparable to an experienced ophthalmologist. In addition, this system can automatically provide guidance to patients regarding appropriate preoperative posturing to reduce retinal detachment progression and the urgency of retinal detachment repair. The implementation of this system on a global scale may drastically reduce the extent of vision impairment resulting from retinal detachment by providing timely identification and referral.

          Abstract

          Li et al. develop a cascaded deep learning system for automated retinal detachment and macular status detection based on ultra-widefield fundus (UWF) images. With reliable and comparable performance to an experienced opthamologist, this system can also provide guidance to patients regarding appropriate preoperative posturing to reduce RD progression.

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          Most cited references30

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          Automated Identification of Diabetic Retinopathy Using Deep Learning

          Diabetic retinopathy (DR) is one of the leading causes of preventable blindness globally. Performing retinal screening examinations on all diabetic patients is an unmet need, and there are many undiagnosed and untreated cases of DR. The objective of this study was to develop robust diagnostic technology to automate DR screening. Referral of eyes with DR to an ophthalmologist for further evaluation and treatment would aid in reducing the rate of vision loss, enabling timely and accurate diagnoses.
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            Efficacy of a Deep Learning System for Detecting Glaucomatous Optic Neuropathy Based on Color Fundus Photographs

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              • Article: not found

              Grader Variability and the Importance of Reference Standards for Evaluating Machine Learning Models for Diabetic Retinopathy

              Use adjudication to quantify errors in diabetic retinopathy (DR) grading based on individual graders and majority decision, and to train an improved automated algorithm for DR grading.
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                Author and article information

                Contributors
                haot.lin@hotmail.com
                Journal
                Commun Biol
                Commun Biol
                Communications Biology
                Nature Publishing Group UK (London )
                2399-3642
                8 January 2020
                8 January 2020
                2020
                : 3
                : 15
                Affiliations
                [1 ]ISNI 0000 0001 2360 039X, GRID grid.12981.33, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, , Sun Yat-sen University, ; Guangzhou, 510060 China
                [2 ]ISNI 0000 0001 2360 039X, GRID grid.12981.33, Centre for Precision Medicine, , Sun Yat-sen University, ; Guangzhou, 510060 China
                [3 ]Shenzhen Eye Hospital, Shenzhen Key Laboratory of Ophthalmology, Affiliated Shenzhen Eye Hospital of Jinan University, Shenzhen, 518001 China
                [4 ]ISNI 0000 0004 1936 8606, GRID grid.26790.3a, Department of Molecular and Cellular Pharmacology, , University of Miami Miller School of Medicine, ; Miami, Florida 33136 USA
                [5 ]ISNI 0000 0001 0707 115X, GRID grid.440736.2, School of Computer Science and Technology, , Xidian University, ; Xi’an, 710071 China
                [6 ]ISNI 0000 0001 0706 4670, GRID grid.272555.2, Singapore National Eye Centre, , Singapore Eye Research Institute, ; 168751 Singapore, Singapore
                [7 ]ISNI 0000 0001 2180 6431, GRID grid.4280.e, Duke-NUS Medical School, , National University of Singapore, ; Singapore, 119077 Singapore
                Author information
                http://orcid.org/0000-0001-5701-0857
                http://orcid.org/0000-0001-9054-288X
                http://orcid.org/0000-0003-4672-9721
                Article
                730
                10.1038/s42003-019-0730-x
                6949241
                31925315
                7b45daef-5374-4092-8a8a-9e69f1899e1c
                © The Author(s) 2020

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 21 September 2019
                : 6 December 2019
                Funding
                Funded by: FundRef https://doi.org/10.13039/501100001809, National Natural Science Foundation of China (National Science Foundation of China);
                Award ID: 81770967
                Award Recipient :
                Funded by: National Key R&D Program of China (grant no. 2018YFC0116500), National Natural Science Fund for Distinguished Young Scholars (grant no. 81822010), the Science and Technology Planning Projects of Guangdong Province (grant no. 2018B010109008), and the Key Research Plan for the National Natural Science Foundation of China in Cultivation Project (grant no. 91846109).
                Categories
                Article
                Custom metadata
                © The Author(s) 2020

                health sciences,translational research,retinal diseases,medical research

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