Impaired Secretin Release in Chronic Alcoholic Dogs

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Abstract

Plasma immunoreactive secretin has been compared before and after stimulation by intraduodenal infusion of HCl in 3 dogs who had received 2 g·kg<sup>-1</sup>. day<sup>-1</sup> alcohol for 3 years and 4 non-alcoholic control dogs. After HCl infusion, blood secretin was lower in chronic alcoholic animals than in controls. This decreased post-stimulation concentration of secretin in chronic alcoholic dogs was in contrast to the increased release of gastrin after a meal which has been previously described.

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Journal ID (publisher-id): DIG

Journal ID (nlm-ta): Digestion

Journal ID (doi): 10.1159/issn.0012-2823

Title: Digestion

Publisher: S. Karger AG

ISSN (Print): 0012-2823

ISSN (Electronic): 1421-9867

Publication date Subscription-year: 1978

Publication date (Print): 1978

Publication date (Electronic): 27 January 2009

Volume: 17

Issue: 5

Pages: 437-440

Affiliations

Unité de Recherches de Pathologie Digestive U 31 Inserm, and Department of Medicine, Hammersmith Hospital, London

Article

Publisher ID: 198147 Other ID: Digestion 1978;17:437–440

DOI: 10.1159/000198147

PubMed ID: 567156

SO-VID: 7ca949bc-813e-4a09-8419-5619f3decdf3

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 23 August 1977

Date accepted : 23 December 1977

Page count

Pages: 4

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Impaired Secretin Release in Chronic Alcoholic Dogs

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Karger: Gastroenterology

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