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      Susceptibility to amphotericin B of Candida spp. strains isolated in Ceará, Northeastern Brazil

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          Abstract

          IntroductionAmphotericin B (AMB) is an antifungal agent used extensively in clinical medicine, yet resistance remains low. This study aims to evaluate the susceptibility of Candida spp. against AMB.MethodsFor broth microdilution susceptibility testing, 77 strains of Candida spp. were selected (32 C. albicans, 33 C. tropicalis, and 12 C. parapsilosis). The strains were considered susceptible when they exhibited MIC≤1.0µg/ml.ResultsNone of the strains showed an MIC greater than 0.25µg/ml.ConclusionsFurther works are necessary, with a higher number of strains, to assess the validity of the results used in this study.

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          Synthesis and biological evaluation of amphotericin B derivatives.

          Astrid Volmer, Alex M Szpilman, Erick M. Carreira (2010)
          Article 0 comments Cited 32 times – based on 0 reviews     Review now
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            Antifungal therapy in invasive fungal infections.

            Sharon Chen, E Playford, Tania C. Sorrell (2010)
            Early treatment of invasive fungal infections (IFIs) is essential for optimal clinical outcomes. Standard antifungal drugs (polyenes, azoles and echinocandins) are not predictably effective against emerging yeasts and filamentous fungi and may cause undesirable side effects. Species identification can guide antifungal selection for invasive candidiasis, but not less common moulds such as Scedosporium and Fusarium spp. Management strategies targeted to those at highest risk (prophylaxis), those with clinical signs of infection not responsive to antibacterials (empiric therapy) and those with occult infection (asymptomatic but with positive fungal biomarkers) produce better outcomes than therapy predicated on identification of a fungal pathogen, but require comparative evaluation. Appropriate dosing and consideration of pharmacokinetic parameters (including therapeutic drug monitoring) are important with newer triazoles. New therapies such as addition of the iron chelator, deferasirox, in the treatment of zygomycosis in diabetic patients, appear promising but additional agents with new targets of action are urgently needed. Crown Copyright © 2010. Published by Elsevier Ltd. All rights reserved.
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              Antifungal susceptibility testing of Candida isolates from the Candida surveillance study.

              Sulaiman Karatela, Yaffa Adiri, G. Reid Lyon … (2010)
              Candida species are a common cause of nosocomial bloodstream infections. Recent surveillance has shown an increase in the relative proportion of infections caused by Candida glabrata, which has reduced susceptibility to fluconazole. We undertook sentinel surveillance with antifungal susceptibility testing to monitor the trends in the proportions of various Candida species causing invasive disease. Forty-one institutions participated in the Candida Surveillance Study. All isolates were submitted to a central laboratory for identification and susceptibility testing. Susceptibility testing was performed in compliance with CLSI guidelines using a custom, broth dilution, microtiter system. There were 5,900 isolates submitted for identification and antifungal susceptibility testing. The distribution of species was as follows: C. albicans, 2,567 (43.5%) isolates; C. glabrata, 1,464 (24.8%) isolates; C. parapsilosis, 1,048 (17.8%) isolates; C. tropicalis, 527 (8.9%) isolates; C. krusei, 109 (1.9%) isolates; C. lusitaniae, 76 (1.3%) isolates; and other Candida species, 109 (1.9%) isolates. Resistance to fluconazole occurred in 1.2% of C. albicans isolates, 5.9% of C. glabrata isolates, 0.3% of C. parapsilosis isolates, and 0.4% of C. tropicalis isolates. Resistance to fluconazole was highly predictive of resistance to voriconazole. Resistance to echinocandins was rarely found, occurring in only 0.2% of all isolates. The rate of fluconazole susceptibility increased significantly from 87.5% in 2005 to 97.4% in 2007. The proportion of cases of disease caused by various Candida species did not change appreciably between 2004 and 2007, and the rate of antifungal susceptibility was high.
              Article 0 comments Cited 28 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Cecília Rocha da Silva: Role: ND
                Hemerson Iury Ferreira Magalhães: Role: ND
                Manoel Odorico de Moraes: Role: ND
                Hélio Vitoriano Nobre Júnior: Role: ND
                Journal
                Journal ID (publisher): rsbmt
                Title: Revista da Sociedade Brasileira de Medicina Tropical
                Abbreviated Title: Rev. Soc. Bras. Med. Trop.
                Publisher: Sociedade Brasileira de Medicina Tropical - SBMT (Uberaba )
                ISSN: 1678-9849
                Publication date (Print): April 2013
                Volume: 46
                Issue: 2
                Pages: 244-245
                Affiliations
                [1 ] Universidade Federal do Ceará Brazil
                [2 ] Universidade Federal do Ceará Brazil
                Article
                Publisher ID: S0037-86822013000200244
                DOI: 10.1590/0037-8682-1060-2013
                PubMed ID: 23740062
                SO-VID: 7cd318f3-9340-42cb-b0c3-4c33ead40ffa
                License:

                http://creativecommons.org/licenses/by/4.0/

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                Product

                SciELO Brazil

                Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=0037-8682&lng=en
                Categories
                Subject: TROPICAL MEDICINE

                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: Amphotericin B,Candida spp,Protocol M27-A3
                Data availability:
                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: Amphotericin B, Candida spp, Protocol M27-A3

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