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      The Impact of Different Levels of Adaptive Iterative Dose Reduction 3D on Image Quality of 320-Row Coronary CT Angiography: A Clinical Trial

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          Abstract

          Purpose

          The aim of this study was the systematic image quality evaluation of coronary CT angiography (CTA), reconstructed with the 3 different levels of adaptive iterative dose reduction (AIDR 3D) and compared to filtered back projection (FBP) with quantum denoising software (QDS).

          Methods

          Standard-dose CTA raw data of 30 patients with mean radiation dose of 3.2 ± 2.6 mSv were reconstructed using AIDR 3D mild, standard, strong and compared to FBP/QDS. Objective image quality comparison (signal, noise, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), contour sharpness) was performed using 21 measurement points per patient, including measurements in each coronary artery from proximal to distal.

          Results

          Objective image quality parameters improved with increasing levels of AIDR 3D. Noise was lowest in AIDR 3D strong (p≤0.001 at 20/21 measurement points; compared with FBP/QDS). Signal and contour sharpness analysis showed no significant difference between the reconstruction algorithms for most measurement points. Best coronary SNR and CNR were achieved with AIDR 3D strong. No loss of SNR or CNR in distal segments was seen with AIDR 3D as compared to FBP.

          Conclusions

          On standard-dose coronary CTA images, AIDR 3D strong showed higher objective image quality than FBP/QDS without reducing contour sharpness.

          Trial Registration

          Clinicaltrials.gov NCT00967876

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          Most cited references35

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          Associations between HIV infection and subclinical coronary atherosclerosis.

          Wendy Post, Matthew Budoff, Lawrence Kingsley … (2014)
          Coronary artery disease (CAD) has been associated with HIV infection, but data are not consistent.
          Article 0 comments Cited 99 times – based on 0 reviews     Review now
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            Iterative reconstruction techniques for computed tomography Part 1: technical principles.

            R Budde, Arnold Schilham, A. de Boer … (2013)
            To explain the technical principles of and differences between commercially available iterative reconstruction (IR) algorithms for computed tomography (CT) in non-mathematical terms for radiologists and clinicians. Technical details of the different proprietary IR techniques were distilled from available scientific articles and manufacturers' white papers and were verified by the manufacturers. Clinical results were obtained from a literature search spanning January 2006 to January 2012, including only original research papers concerning IR for CT. IR for CT iteratively reduces noise and artefacts in either image space or raw data, or both. Reported dose reductions ranged from 23 % to 76 % compared to locally used default filtered back-projection (FBP) settings, with similar noise, artefacts, subjective, and objective image quality. IR has the potential to allow reducing the radiation dose while preserving image quality. Disadvantages of IR include blotchy image appearance and longer computational time. Future studies need to address differences between IR algorithms for clinical low-dose CT. • Iterative reconstruction technology for CT is presented in non-mathematical terms. • IR reduces noise and artefacts compared to filtered back-projection. • IR can improve image quality in routine-dose CT and lower the radiation dose. • IR's disadvantages include longer computation and blotchy appearance of some images.
            Article 0 comments Cited 81 times – based on 0 reviews     Review now
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              Innovations in CT dose reduction strategy: application of the adaptive statistical iterative reconstruction algorithm.

              A. T. Hara, Jennifer Kujak, A. Silva … (2009)
              The purpose of this article is to discuss the application of a new CT reconstruction algorithm, adaptive statistical iterative reconstruction (ASIR), to reduce radiation dose at body CT and to provide imaging examples in comparison with low-dose and standard-dose filtered back projection CT. The ASIR reconstruction algorithm is a promising technique for providing diagnostic quality CT images at significantly reduced radiation doses.
              Article 0 comments Cited 76 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Elena Cavarretta: Role: Academic Editor
                Journal
                Journal ID (nlm-ta): PLoS One
                Journal ID (iso-abbrev): PLoS ONE
                Journal ID (publisher-id): plos
                Journal ID (pmc): plosone
                Title: PLoS ONE
                Publisher: Public Library of Science (San Francisco, CA USA )
                ISSN (Electronic): 1932-6203
                Publication date (Electronic): 6 May 2015
                Publication date Collection: 2015
                Volume: 10
                Issue: 5
                Electronic Location Identifier: e0125943
                Affiliations
                [1 ]Department of Radiology, Charité Medical School, Humboldt-Universität zu Berlin, Freie Universität Berlin, Berlin, Germany
                [2 ]Department of Radiology, Charité Medical School, Berlin, Germany
                [3 ]Toshiba Medical Systems Europe B.V., Zoetermeer, the Netherlands
                [4 ]Department of Medical Statistics, Informatics and Documentation, University Hospital of Friedrich-Schiller University Jena, Jena, Germany
                Sapienza University of Rome, ITALY
                Author notes

                Competing Interests: Prof. Dewey has received grant support from the Heisenberg Program of the DFG for a professorship (DE 1361/14-1), the FP7 Program of the European Commission for the randomized multicenter DISCHARGE trial (603266-2, HEALTH-2012.2.4.-2), the European Regional Development Fund (20072013 2/05, 20072013 2/48), the German Heart Foundation/German Foundation of Heart Research (F/23/08, F/27/10), the Joint Program from the German Research Foundation (DFG) and the German Federal Ministry of Education and Research (BMBF) for meta-analyses (01KG1013, 01KG1110, 01KG1110), GE Healthcare, Bracco, Guerbet, and Toshiba Medical Systems. The CARS-320 study has received grants from Bracco. Prof. Dewey has received lecture fees from Toshiba Medical Systems, Guerbet, Cardiac MR Academy Berlin, and Bayer (Schering-Berlex). Prof. Dewey is a consultant to Guerbet and one of the principal investigators of multi-center studies (CORE-64 and 320) on coronary CT angiography sponsored by Toshiba Medical Systems. He is also the editor of Coronary CT Angiography and Cardiac CT, both published by Springer, and offers hands-on workshops on cardiovascular imaging ( www.ct-kurs.de). Prof. Dewey is an associate editor of Radiology and European Radiology. Dr. Jörg Blobel and Dr. Joanne Schuijf are full-time employees of Toshiba Medical Systems Europe. Institutional master research agreements exist with Siemens Medical Solutions, Philips Medical Systems, and Toshiba Medical Systems. The terms of these arrangements are managed by the legal department of Charité – Universitätsmedizin Berlin. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. The authors have full control control of all primary data. All funders (TMS, Guerbet, CMR Bayer, Siemens) provided support in form of salaries, but did not have any role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the “author contributions`section”. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials. Two employees from Toshiba Medical System (JB and JS) gave their input into the manuscript and, due to that, are listed as authors.

                Conceived and designed the experiments: MD MR EZ. Performed the experiments: MD MR EZ SF. Analyzed the data: SF PM FR. Contributed reagents/materials/analysis tools: SF MD MR EZ PM FR JB JS. Wrote the paper: SF MD MR EZ JS JB.

                Article
                Publisher ID: PONE-D-15-02439
                DOI: 10.1371/journal.pone.0125943
                PMC ID: 4422621
                PubMed ID: 25945924
                SO-VID: 7da708d3-9a06-4a13-8743-7921f044523b
                Copyright statement: Copyright @ 2015
                License:

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

                History
                Date received : 18 January 2015
                Date accepted : 22 March 2015
                Page count
                Figures: 6, Tables: 2, Pages: 16
                Funding
                The authors of this manuscript declare relationships with the following companies: Prof. Dewey has received grant support from the Heisenberg Program of the DFG for a professorship (DE 1361/14-1), the FP7 Program of the European Commission for the randomized multicenter DISCHARGE trial (603266-2, HEALTH-2012.2.4.-2), the European Regional Development Fund (20072013 2/05, 20072013 2/48), the German Heart Foundation/German Foundation of Heart Research (F/23/08, F/27/10), the Joint Program from the German Research Foundation (DFG) and the German Federal Ministry of Education and Research (BMBF) for meta-analyses (01KG1013, 01KG1110, 01KG1110), GE Healthcare, Bracco, Guerbet, and Toshiba Medical Systems. The CARS-320 study has received grants from Bracco. Prof. Dewey has received lecture fees from Toshiba Medical Systems, Guerbet, Cardiac MR Academy Berlin, and Bayer (Schering-Berlex). Prof. Dewey is a consultant to Guerbet and one of the principal investigators of multi-center studies (CORE-64 and 320) on coronary CT angiography sponsored by Toshiba Medical Systems. He is also the editor of Coronary CT Angiography and Cardiac CT, both published by Springer, and offers hands-on workshops on cardiovascular imaging ( www.ct-kurs.de). Prof. Dewey is an associate editor of Radiology and European Radiology. Dr. Jörg Blobel and Dr. Joanne Schuijf are full-time employees of Toshiba Medical Systems Europe. Institutional master research agreements exist with Siemens Medical Solutions, Philips Medical Systems, and Toshiba Medical Systems. The terms of these arrangements are managed by the legal department of Charité – Universitätsmedizin Berlin. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. The authors have full control control of all primary data. All funders (TMS, Guerbet, CMR Bayer, Siemens) provided support in form of salaries, but did not have any role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the “author contributions`section”.
                Categories
                Subject: Research Article
                Custom metadata
                Data Availability All relevant data are within the paper and its Supporting Information files.

                ScienceOpen disciplines: Uncategorized
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