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Heterosexual HIV-1 infectiousness and antiretroviral use: systematic review of prospective studies of discordant couples.
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Abstract
Recent studies have estimated the reduction in HIV-1 infectiousness with antiretroviral therapy (ART), but high-quality studies such as randomized controlled trials, accompanied by rigorous adherence counseling, are likely to overestimate the effectiveness of treatment-as-prevention in real-life settings.