- Record: found
- Abstract: found
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Frédéric Fabre ^{1} ^{,} ^{*} ,
Josselin Montarry ^{1} ^{,} ^{2} ,
Jérôme Coville ^{3} ,
Rachid Senoussi ^{3} ,
Vincent Simon ^{1} ,
Benoît Moury ^{1}

19 April 2012

Uncovering how natural selection and genetic drift shape the evolutionary dynamics
of virus populations within their hosts can pave the way to a better understanding
of virus emergence. Mathematical models already play a leading role in these studies
and are intended to predict future emergences. Here, using high-throughput sequencing,
we analyzed the within-host population dynamics of four
*Potato virus Y* (PVY) variants differing at most by two substitutions involved in pathogenicity properties.
Model selection procedures were used to compare experimental results to six hypotheses
regarding competitiveness and intensity of genetic drift experienced by viruses during
host plant colonization. Results indicated that the frequencies of variants were well
described using Lotka-Volterra models where the competition coefficients
*β
_{ij}
* exerted by variant

Natural selection and genetic drift drive the evolution of virus populations within
their hosts and therefore influence strongly virus emergences. To help predict future
virus emergences, we developed a model that estimates simultaneously genetic drift
and selection intensities using high-throughput sequence data representing the within-host
population dynamics of
*Potato virus Y* variants differing at most by two substitutions involved in pathogenicity properties.
The competitiveness costs induced by these mutations as well as the mathematical expressions
of the competition coefficients of virus variants were derived from Lotka–Volterra
equations. High genetic differentiation of virus populations between hosts was evidenced
as well as its hump-shaped behaviour with time. The modelling framework proposed here
was intended to help design control strategies aiming to prevent virus emergences.

- Record: found
- Abstract: not found
- Article: not found

S. Wright (1931)

- Record: found
- Abstract: found
- Article: found

Susan M. Huse, Julie A. Huber, Hilary G. Morrison … (2007)

- Record: found
- Abstract: found
- Article: not found

K. Anderson, Seth Epstein, Francisco Olivas … (2004)

Public Library of Science
(San Francisco, USA
)

1553-7366

1553-7374

Pages: 9