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      Dynamic time window mechanism for time synchronous VEP-based BCIs—Performance evaluation with a dictionary-supported BCI speller employing SSVEP and c-VEP

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          Abstract

          Brain-Computer Interfaces (BCIs) based on visual evoked potentials (VEPs) allow high communication speeds and accuracies. The fastest speeds can be achieved if targets are identified in a synchronous way (i.e., after a pre-set time period the system will produce a command output). The duration a target needs to be fixated on until the system classifies an output command affects the overall system performance. Hence, extracting a data window dedicated for the classification is of critical importance for VEP-based BCIs. Secondly, unintentional fixation on a target could easily lead to its selection. For the practical usability of BCI applications it is desirable to distinguish between intentional and unintentional fixations. This can be achieved by using threshold-based target identification methods. The study explores personalized dynamic classification time windows for threshold-based time synchronous VEP BCIs. The proposed techniques were tested employing the SSVEP and the c-VEP paradigm. Spelling performance was evaluated using an 8-target dictionary-supported BCI utilizing an n-gram word prediction model. The performance of twelve healthy participants was assessed with the information transfer rate (ITR) and accuracy. All participants completed sentence spelling tasks, reaching average accuracies of 94% and 96.3% for the c-VEP and the SSVEP paradigm, respectively. Average ITRs around 57 bpm were achieved for both paradigms.

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          Most cited references21

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          10/20, 10/10, and 10/5 systems revisited: their validity as relative head-surface-based positioning systems.

          With the advent of multi-channel EEG hardware systems and the concurrent development of topographic and tomographic signal source localization methods, the international 10/20 system, a standard system for electrode positioning with 21 electrodes, was extended to higher density electrode settings such as 10/10 and 10/5 systems, allowing more than 300 electrode positions. However, their effectiveness as relative head-surface-based positioning systems has not been examined. We previously developed a virtual 10/20 measurement algorithm that can analyze any structural MR head and brain image. Extending this method to the virtual 10/10 and 10/5 measurement algorithms, we analyzed the MR images of 17 healthy subjects. The acquired scalp positions of the 10/10 and 10/5 systems were normalized to the Montreal Neurological Institute (MNI) stereotactic coordinates and their spatial variability was assessed. We described and examined the effects of spatial variability due to the selection of positioning systems and landmark placement strategies. As long as a detailed rule for a particular system was provided, it yielded precise landmark positions on the scalp. Moreover, we evaluated the effective spatial resolution of 329 scalp landmark positions of the 10/5 system for multi-subject studies. As long as a detailed rule for landmark setting was provided, 241 scalp positions could be set effectively when there was no overlapping of two neighboring positions. Importantly, 10/10 positions could be well separated on a scalp without overlapping. This study presents a referential framework for establishing the effective spatial resolutions of 10/20, 10/10, and 10/5 systems as relative head-surface-based positioning systems.
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            A brain-computer interface controlled auditory event-related potential (p300) spelling system for locked-in patients.

            Using brain-computer interfaces (BCI) humans can select letters or other targets on a computer screen without any muscular involvement. An intensively investigated kind of BCI is based on the recording of visual event-related brain potentials (ERP). However, some severely paralyzed patients who need a BCI for communication have impaired vision or lack control of gaze movement, thus making a BCI depending on visual input no longer feasible. In an effort to render the ERP-BCI usable for this group of patients, the ERP-BCI was adapted to auditory stimulation. Letters of the alphabet were assigned to cells in a 5 x 5 matrix. Rows of the matrix were coded with numbers 1 to 5, and columns with numbers 6 to 10, and the numbers were presented auditorily. To select a letter, users had to first select the row and then the column containing the desired letter. Four severely paralyzed patients in the end-stage of a neurodegenerative disease were examined. All patients performed above chance level. Spelling accuracy was significantly lower with the auditory system as compared with a similar visual system. Patients reported difficulties in concentrating on the task when presented with the auditory system. In future studies, the auditory ERP-BCI should be adjusted by taking into consideration specific features of severely paralyzed patients, such as reduced attention span. This adjustment in combination with more intensive training will show whether an auditory ERP-BCI can become an option for visually impaired patients.
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              Frequency recognition based on canonical correlation analysis for SSVEP-based BCIs.

              Canonical correlation analysis (CCA) is applied to analyze the frequency components of steady-state visual evoked potentials (SSVEP) in electroencephalogram (EEG). The essence of this method is to extract a narrowband frequency component of SSVEP in EEG. A recognition approach is proposed based on the extracted frequency features for an SSVEP-based brain computer interface (BCI). Recognition Results of the approach were higher than those using a widely used FFT (fast Fourier transform)-based spectrum estimation method.
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                Author and article information

                Contributors
                Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole: MethodologyRole: SoftwareRole: ValidationRole: VisualizationRole: Writing – original draftRole: Writing – review & editing
                Role: Data curationRole: Formal analysisRole: MethodologyRole: Software
                Role: Software
                Role: Funding acquisitionRole: MethodologyRole: Project administrationRole: ResourcesRole: SoftwareRole: SupervisionRole: ValidationRole: Writing – review & editing
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                2019
                13 June 2019
                : 14
                : 6
                : e0218177
                Affiliations
                [001] Faculty of Technology and Bionics, Rhine-Waal University of Applied Sciences, 47533 Kleve, Germany
                Columbia University, UNITED STATES
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                Author information
                http://orcid.org/0000-0002-4193-2993
                http://orcid.org/0000-0002-0935-2884
                http://orcid.org/0000-0001-6555-7617
                Article
                PONE-D-18-34251
                10.1371/journal.pone.0218177
                6564540
                31194817
                7e8f4aa4-baaa-471a-b49f-854352c59237
                © 2019 Gembler et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 7 December 2018
                : 28 May 2019
                Page count
                Figures: 4, Tables: 4, Pages: 18
                Funding
                This research was supported by the European Fund for Regional Development (EFRD - or EFRE in German) under Grants GE-1-1-047, and IT-1-2-001. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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                Custom metadata
                The data sets cannot be shared according to legal guidelines. All participants were informed that their data will be deleted after a certain time period. This study was approved by the ethics committee of: Ethik-Kommission / Medizinische Fakultät der Universität Duisburg-Essen Robert-Koch-Str. 9, 45147 Essen. Fax: +49 (0) 201/723-1847. E-mail: ethikkommission@ 123456uk-essen.de . Website: www.uni-due.de/ethikkommission.

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