Efficacy of human C1 esterase inhibitor concentrate for treatment of ACE-inhibitor induced angioedema.

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Abstract

ACE inhibitor (ACEi) induced angioedema predominantly affects the upper aerodigestive tract. As ACEi induced angioedema is mediated by bradykinin, therapeutic response to antihistamines and glucocorticoids remains unsatisfactory. In bradykinin mediated hereditary angioedema, C1-esterase inhibitor (C1INH) is an effective and approved treatment since many years. Our aim was to evaluate the therapeutic effect of C1INH in ACEi induced angioedema.

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Journal

Journal ID (iso-abbrev): Am J Emerg Med

Title: The American journal of emergency medicine

Publisher: Elsevier BV

ISSN (Electronic): 1532-8171

ISSN (Print): 0735-6757

Publication date (Electronic): Feb 2023

Volume: 64

Affiliations

[1 ] Department of Otorhinolaryngology, Klinikum rechts der Isar, Technische Universität München, Germany. Electronic address: u.strassen@tum.de.

[2 ] Department of Otorhinolaryngology, Klinikum rechts der Isar, Technische Universität München, Germany.

[3 ] Department of Otorhinolaryngology, Grosshadern Medical Center of the University of Munich, Germany.

[4 ] Department of Otorhinolaryngology, Ruhr-University of Bochum, St. Elisabeth-Hospital Bochum, Germany.

[5 ] Munich Study Center, Faculty of Medicine, Technical University Munich, Germany; Institute for AI and Informatics in Medicine, Faculty of Medicine, Technical University Munich, Germany.

[6 ] Institute of Pharmacology and Clinical Pharmacology, University Hospital Düsseldorf, Düsseldorf (G.K.), Germany.

[7 ] Department of Otorhinolaryngology, Head and Neck Surgery, Ulm University, Medical Center, Ulm, Germany.

[8 ] Department of Otorhinolaryngology, Klinikum rechts der Isar, Technische Universität München, Germany; Department of Otorhinolaryngology, Head and Neck Surgery, Ulm University, Medical Center, Ulm, Germany.

Article

Publisher Item ID: S0735-6757(22)00743-4

DOI: 10.1016/j.ajem.2022.12.001

PubMed ID: 36516670

SO-VID: 7ee33a95-1f9f-49bc-930b-f105d68b341c

History

Keywords: ACE induced angioedema,Bradykinin,C1-inhibitor-concentrate,Drug induced angioedema

Data availability:

Keywords: ACE induced angioedema, Bradykinin, C1-inhibitor-concentrate, Drug induced angioedema

Efficacy of human C1 esterase inhibitor concentrate for treatment of ACE-inhibitor induced angioedema.

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