<div class="section">
<a class="named-anchor" id="S1">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d10810414e251">Background</h5>
<p id="P1">The influence of insulin and insulin resistance (IR) on children’s weight
and fat
gain is unclear.
</p>
</div><div class="section">
<a class="named-anchor" id="S2">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d10810414e256">Objective</h5>
<p id="P2">To evaluate insulin and IR as predictors of weight and body fat gain in
children at
high-risk for adult obesity. We hypothesized that baseline IR would be positively
associated with follow-up BMI and fat mass.
</p>
</div><div class="section">
<a class="named-anchor" id="S3">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d10810414e261">Subjects/Methods</h5>
<p id="P3">249 healthy African American and Caucasian children, age 6–12y, at high-risk
for adult
obesity because of early-onset childhood overweight and/or parental overweight, were
followed for up to 15y with repeated BMI and fat mass measurements. We examined baseline
serum insulin and HOMA-IR as predictors of follow-up BMI Z score and fat mass by DEXA
in mixed model longitudinal analyses accounting for baseline body composition, pubertal
stage, sociodemographic factors, and follow-up interval.
</p>
</div><div class="section">
<a class="named-anchor" id="S4">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d10810414e266">Results</h5>
<p id="P4">At baseline, 39% were obese (BMI ≥95th percentile for age/sex). Data from
1,335 annual
visits were examined. Children were followed for an average of 7.2±4.3y, with a maximum
follow up of 15 years. After accounting for covariates, neither baseline insulin nor
HOMA-IR was significantly associated with follow up BMI (p’s>.26), BMIz score (p’s>.22),
fat mass (p’s>.78), or fat mass percentage (p’s>.71). In all models, baseline
BMI
(p<.0001), body fat mass (p<.0001), and percentage fat (p<.001) were strong
positive
predictors for change in BMI and fat mass. In models restricted to children without
obesity at baseline, some but not all models had significant interaction terms between
body adiposity and insulinemia/HOMA-IR that suggested less gain in mass among those
with greater insulin or insulin resistance. The opposite was found in some models
restricted to children with obesity at baseline.
</p>
</div><div class="section">
<a class="named-anchor" id="S5">
<!--
named anchor
-->
</a>
<h5 class="section-title" id="d10810414e271">Conclusions</h5>
<p id="P5">In middle childhood, BMI and fat mass, but not insulin or IR, are strong
predictors
of children’s gains in BMI and fat mass during adolescence.
</p>
</div>