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      PTSD as the second tsunami of the SARS-Cov-2 pandemic

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      Psychological Medicine
      Cambridge University Press

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          Abstract

          Since the first cases, the coronavirus disease (COVID-19) rapidly spread around the world, with hundred−thousand cases and thousands of deaths. Post-traumatic stress disorder (PTSD) is a common consequence of major disasters. Exceptional epidemic situations also promoted PTSD in the past. Considering that humanity is undergoing the most severe pandemic since Spanish Influenza, the actual pandemic of COVID-19 is very likely to promote PTSD. Moreover, COVID-19 was renamed severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2). With a poor understanding of viruses and spreading mechanisms, the evocation of SARS is generating a great anxiety contributing to promote PTSD. Quarantine of infected patients evolved to quarantine of ‘infected’ towns or popular districts, and then of entire countries. In the families of cases, the brutal death of family members involved a spread of fear and a loss of certainty, promoting PTSD. In the context of disaster medicine with a lack of human and technical resources, healthcare workers could also develop acute stress disorders, potentially degenerating into chronic PTSD. Globally, WHO estimates 30–50% of the population affected by a disaster suffered from diverse psychological distress. PTSD individuals are more at-risk of suicidal ideation, suicide attempt, and deaths by suicide – considering that healthcare workers are already at-risk occupations. We draw attention towards PTSD as a secondary effect of the SARS-Cov-2 pandemic, both for general population, patients, and healthcare workers. Healthcare policies need to take into account preventive strategy of PTSD, and the related risk of suicide, in forthcoming months.

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          Most cited references20

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          Immediate Psychological Responses and Associated Factors during the Initial Stage of the 2019 Coronavirus Disease (COVID-19) Epidemic among the General Population in China

          Background: The 2019 coronavirus disease (COVID-19) epidemic is a public health emergency of international concern and poses a challenge to psychological resilience. Research data are needed to develop evidence-driven strategies to reduce adverse psychological impacts and psychiatric symptoms during the epidemic. The aim of this study was to survey the general public in China to better understand their levels of psychological impact, anxiety, depression, and stress during the initial stage of the COVID-19 outbreak. The data will be used for future reference. Methods: From 31 January to 2 February 2020, we conducted an online survey using snowball sampling techniques. The online survey collected information on demographic data, physical symptoms in the past 14 days, contact history with COVID-19, knowledge and concerns about COVID-19, precautionary measures against COVID-19, and additional information required with respect to COVID-19. Psychological impact was assessed by the Impact of Event Scale-Revised (IES-R), and mental health status was assessed by the Depression, Anxiety and Stress Scale (DASS-21). Results: This study included 1210 respondents from 194 cities in China. In total, 53.8% of respondents rated the psychological impact of the outbreak as moderate or severe; 16.5% reported moderate to severe depressive symptoms; 28.8% reported moderate to severe anxiety symptoms; and 8.1% reported moderate to severe stress levels. Most respondents spent 20–24 h per day at home (84.7%); were worried about their family members contracting COVID-19 (75.2%); and were satisfied with the amount of health information available (75.1%). Female gender, student status, specific physical symptoms (e.g., myalgia, dizziness, coryza), and poor self-rated health status were significantly associated with a greater psychological impact of the outbreak and higher levels of stress, anxiety, and depression (p < 0.05). Specific up-to-date and accurate health information (e.g., treatment, local outbreak situation) and particular precautionary measures (e.g., hand hygiene, wearing a mask) were associated with a lower psychological impact of the outbreak and lower levels of stress, anxiety, and depression (p < 0.05). Conclusions: During the initial phase of the COVID-19 outbreak in China, more than half of the respondents rated the psychological impact as moderate-to-severe, and about one-third reported moderate-to-severe anxiety. Our findings identify factors associated with a lower level of psychological impact and better mental health status that can be used to formulate psychological interventions to improve the mental health of vulnerable groups during the COVID-19 epidemic.
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            Long-term psychiatric morbidities among SARS survivors

            Objective Severe acute respiratory syndrome (SARS) was the first massive infectious disease outbreak of the 21st century. However, it is unlikely that this outbreak will be the last. This study aimed to evaluate the long-term psychiatric morbidities in survivors of SARS. Method This is a cohort study designed to investigate psychiatric complications among SARS survivors treated in the United Christian Hospital 30 months after the SARS outbreak. Psychiatric morbidities were assessed by the Structured Clinical Interview for DSM-IV, the Impact of Events Scale–Revised and the Hospital Anxiety and Depression Scale. Functional outcomes were assessed by the Medical Outcomes Study 36-Item Short-Form Health Survey. Results Ninety subjects were recruited, yielding a response rate of 96.8%. Post-SARS cumulative incidence of DSM-IV psychiatric disorders was 58.9%. Current prevalence for any psychiatric disorder at 30 months post-SARS was 33.3%. One-fourth of the patients had post-traumatic stress disorder (PTSD), and 15.6% had depressive disorders. Conclusion The outbreak of SARS can be regarded as a mental health catastrophe. PTSD was the most prevalent long-term psychiatric condition, followed by depressive disorders. Our results highlight the need to enhance preparedness and competence of health care professionals in detecting and managing the psychological sequelae of future comparable infectious disease outbreaks.
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              Posttraumatic stress symptoms and attitude toward crisis mental health services among clinically stable patients with COVID-19 in China

              The novel coronavirus disease (COVID-19) has been rapidly transmitted globally. With the increasing number of infected cases and deaths, many patients experienced both physical suffering and great psychological distress. In China, a range of guidelines and expert consensus have been developed by health authorities and academic associations. Crisis mental health interventions, such as online education and counseling services, have been widely adopted nationwide (Liu et al., 2020). According to the treatment guidelines in China, COVID-19 patients need to be treated in isolated hospitals. Due to social isolation, perceived danger, uncertainty, physical discomfort, medication side effects, fear of virus transmission to others, and negative news on social media, patients with COVID-19 may experience loneliness, anger, anxiety, depression, insomnia, and posttraumatic stress symptoms (Wu, Chan, & Ma, 2005; Xiang et al., 2020), which could negatively affect individuals' social and occupational functioning, and quality of life (Monson, Caron, McCloskey, & Brunet, 2017; North et al., 2002). To date, no studies on the pattern of posttraumatic stress symptoms among COVID-19 patients have been reported. Therefore, we examined the pattern of posttraumatic stress symptoms in clinically stable COVID-19 patients. We also explored patients' attitude toward crisis mental health services during the COVID-19 outbreak. Online assessment was incorporated as part of the crisis psychological interventions. Patients were invited to participate in this online assessment prior to their discharge from five quarantine facilities (‘Fang Cang’ hospitals) in Wuhan, Hubei province in March 2020. ‘Fang Cang’ hospitals refer to temporary quarantine hospital facilities converted from gymnasiums, exhibition centers and sports centers for clinically stable patients with COVID-19 in Wuhan, China. To be eligible, participants should be adult patients diagnosed with COVID-19 verified by patients' medical records, and clinically stable, as screened by patients' case medical officers. Participants were asked about their attitudes toward COVID-19-related online crisis mental health services, such as psycho-educational resources, and mental health counseling, using a standardized question: ‘Do you think online psycho-educational resources and mental health counseling provision during the COVID-19 outbreak are helpful?’ (yes/no). The amended self-reported Posttraumatic Stress Disorder (PTSD) Checklist– Civilian Version (PCL-C) (Weathers, Litz, Herman, Huska, & Keane, 1993) was used to assess the severity of the posttraumatic stress symptoms associated with the COVID-19. A total PCL-C score of ⩾50 was considered ‘having significant posttraumatic stress symptoms’ (Yang, Yang, Liu, & Yang, 2007). A total of 730 COVID-19 patients were recruited in this study, of whom, 714 met the inclusion criteria. The mean age of the participants was 50.2 ± 12.9 years, men accounted for 49.1% of the sample, and 25.8% lived alone prior to admission. The prevalence of significant posttraumatic stress symptoms associated with the COVID-19 was 96.2% (95% CI 94.8–97.6%). Half of the participants (49.8%) considered psycho-educational services helpful. To the best of our knowledge, this was the first study examining the prevalence of posttraumatic stress symptoms in COVID-19 patients. It is noteworthy that most COVID-19 patients suffered from significant posttraumatic stress symptoms associated with the disease prior to discharge, and these symptoms may lead to negative outcomes, such as lower quality of life and impaired working performance. Following the outbreak of severe acute respiratory syndrome (SARS) in 2003, the prevalence of PTSD in SARS survivors was 9.79% in their early recovery phase (Fang, Zhe, & Shuran, 2004) and 25.6% at 30-month post-SARS assessment (Mak, Chu, Pan, Yiu, & Chan, 2009). Our findings were significantly higher than that of Fang's and Mak's. The remarkable differences between these studies could be attributed to different clinical diagnosis and illness phrases (e.g., clinically stable COVID-19 inpatients vs. SARS survivors) and different measurements (e.g., self-reported instrument on posttraumatic stress symptoms associated with the COVID-19 vs. clinical diagnosis of PTSD established by professionals). The rapid transmission of COVID-19 alongside with demeaning news coverage in widely used communication programs (e.g. WeChat and Weibo), and social discrimination toward COVID-19 patients may result in higher prevalence of self-perceived posttraumatic stress symptoms associated with the COVID-19 in this study. Of particular note was that only half of the patients hold positive attitudes toward online crisis mental health services. During the COVID-19 outbreak, most crisis mental health services for infected patients are delivered online. Many COVID-19 patients were older adults with limited time, and restricted access to internet and smartphones due to poor health status during hospitalization (Yang et al., 2020). Compared with on-site psychological interventions, online self-guided psycho-educational resources could be less effective, especially for those with reading difficulties and physical discomfort brought by COVID-19 and treatment side effects. In conclusion, this study found that most clinically stable COVID-19 patients suffered from significant posttraumatic stress symptoms associated with the COVID-19 prior to discharge. Considering the negative detrimental impact of significant posttraumatic stress symptoms, appropriate crisis psychological interventions and long-term follow-up assessments should be urgently initiated for COVID-19 survivors.
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                Author and article information

                Journal
                Psychol Med
                Psychol Med
                PSM
                Psychological Medicine
                Cambridge University Press (Cambridge, UK )
                0033-2917
                1469-8978
                24 April 2020
                : 1-2
                Affiliations
                [1 ]Preventive and Occupational Medicine, Université Clermont Auvergne, CNRS, LaPSCo, Physiological and Psychosocial Stress, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand , Witty Fit, F-63000 Clermont-Ferrand, France
                [2 ]Physiological and Psychosocial Stress, Université Clermont Auvergne, CNRS, LaPSCo , F-63000 Clermont-Ferrand, France
                [3 ]Ophthalmology, Université Clermont Auvergne, CNRS, INSERM, GReD, Translational Approach to Epithelial Injury and Repair, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand , F-63000 Clermont-Ferrand, France
                Author notes
                Author for correspondence: Frédéric Dutheil, E-mail: fdutheil@ 123456chu-clermontferrand.fr
                Author information
                https://orcid.org/0000-0001-6317-345X
                Article
                S0033291720001336
                10.1017/S0033291720001336
                7198460
                32326997
                7f75a5b6-bc65-4748-ad85-3a80a826498e
                © The Author(s) 2020

                This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means subject to acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

                History
                : 14 April 2020
                : 19 April 2020
                : 22 April 2020
                Page count
                References: 20, Pages: 2
                Categories
                Correspondence

                Clinical Psychology & Psychiatry
                Clinical Psychology & Psychiatry

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