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      Oleoma treated with oral colchicine: Report of two cases and review of the literature ☆

      case-report

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Oleoma is a non-allergic, foreign body type granulomatous reaction. It appears as response to oily exogenous substances injected to the dermis or subcutis for aesthetical purposes. Treatment for localized lesions is surgical. When they are multiple, steroids may show some result.

          Newer therapeutic possibilities are being introduced and colchicine constitutes an alternative that is financially accessible and safe in moderate doses for certain dermatological illnesses. We present two women with oleoma on the legs treated with oral colchicine. This option was due to the extension of the clinical picture, which would not have a good surgical outcome. There was significant improvement in one patient, while we had to interrupt the medication in the other because of side effects.

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          Histologie diagnosis of inflammatory skin diseases

          BA Ackerman, A.B. ACKERMAN, A.B. Ackerman … (1978)
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            Paraffin oil injection in the body: an obsolete and destructive procedure.

            Marina Pierangeli, Alessandro Scalise, Aldo Bertani … (2002)
            Injection of foreign materials, such as paraffin oil, is an old and obsolete procedure. The authors describe previous uses for this procedure that had been used since the 19th century and the treatment of patients affected by such a disease.
            Article 0 comments Cited 20 times – based on 0 reviews     Review now
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              Serum xylosyltransferase: a new biochemical marker of the sclerotic process in systemic sclerosis.

              C Götting, S Sollberg, J. Kühn … (1999)
              UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase (EC2.4.2.26) is the initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes. Secretion of xylosyltransferase into the extracellular space was determined in cultured human dermal fibroblasts. A more than 6-fold accumulation of xylosyltransferase activity in cell culture supernatant was observed (day 1, 0.6 microU per 106 cells; day 9, 4.1 microU per 106 cells); however, intracellular xylosyltransferase activity remained at a constant level (0.4 microU per 106 cells). Exposure of human chondrocytes to colchicine led to a 3-fold decreased level of xylosyltransferase and chondroitin-6-sulfate concentration in cell culture. Specific xylosyltransferase activity and chondroitin-6-sulfate concentration decreased in a concentration-dependent manner and in parallel in culture medium and accumulated 5-fold in cell lysates indicating that xylosyltransferase is secreted simultaneously into the extracellular space with chondroitin sulfate proteoglycans. Xylosyltransferase activities were determined in serum samples of 30 patients with systemic sclerosis. Xylosyltransferase activities in female (mean value 1.28 mU per liter, 90% range 1.10-1.55 mU per liter) and male patients (mean 1.39 mU per liter, 90% range 1.16-1. 57 mU per liter) with systemic sclerosis were significantly increased in comparison with blood donors of a corresponding age. Furthermore, xylosyltransferase activity was correlated with the clinical classification of systemic sclerosis. Female patients with diffuse cutaneous systemic sclerosis showed higher serum xylosyltransferase activities than patients with limited systemic sclerosis. These results confirm that the increase of proteoglycan biosynthesis in sclerotic processes of scleroderma is closely related to an elevated xylosyltransferase activity in blood and demonstrate the validity of xylosyltransferase as an additional diagnostic marker for determination of sclerotic activity in systemic sclerosis.
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                Author and article information

                Contributors
                Marcia Ramos-e-Silva
                Journal
                Journal ID (nlm-ta): Int J Womens Dermatol
                Journal ID (iso-abbrev): Int J Womens Dermatol
                Title: International Journal of Women's Dermatology
                Publisher: Elsevier
                ISSN (Electronic): 2352-6475
                Publication date PMC-release: 19 February 2015
                Publication date Collection: February 2015
                Publication date (Electronic): 19 February 2015
                Volume: 1
                Issue: 1
                Pages: 47-50
                Affiliations
                [a ]Sector of Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Brazil
                [b ]Sector of Pathology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro
                Author notes
                [* ]Correspondence: Prof. Marcia Ramos-e-Silva, Rua Dona Mariana 143/C-32, 22280–020 Rio de Janeiro Brazil. ramos.e.silva@ 123456dermato.med.br
                Article
                Publisher ID: S2352-6475(14)00005-7
                DOI: 10.1016/j.ijwd.2014.12.004
                PMC ID: 5418667
                SO-VID: 7fc5c5c1-1ec6-486a-af7e-8ac70f89b64d
                Copyright © © 2015 Published by Elsevier Inc. on behalf of Women's Dermatologic Society.
                License:

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                Date received : 3 October 2014
                Date revision received : 30 November 2014
                Date accepted : 15 December 2014
                Categories
                Subject: Case Report

                Keywords: oleoma,colchicine,granuloma
                Data availability:
                Keywords: oleoma, colchicine, granuloma

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