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      [How to test for NTRK gene fusions: A practical approach for pathologists].

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          Abstract

          The recent availability of targeted anti-TRK therapies represents a new opportunity to treat patients with advanced cancers harboring NTRK gene fusions. In this article, we present an update on the practical modalities of implementing a "NTRK testing" to search for these fusions in view of the performances and availability of the different testing methods and the epidemiological characteristics of the tumors liable to present the NTRK1, NTRK2 or NTRK3 gene fusions.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Ann Pathol
          Title: Annales de pathologie
          Publisher: Elsevier BV
          ISSN: 0242-6498
          ISSN (Print): 0242-6498
          Publication date (Electronic): Jul 2021
          Volume: 41
          Issue: 4
          Affiliations
          [1 ] Inserm, CHU de Brest, LBAI, UMR1227, Université Brest, 29200 Brest, France; Service d'anatomie et cytologie pathologiques, CHRU Brest, 29200 Brest, France. Electronic address: arnaud.uguen@chu-brest.fr.
          [2 ] Inserm U1245, service de pathologie, CHU de Rouen, 76031 Rouen, France.
          [3 ] Inserm U1240, département d'anatomie et de cytologie pathologiques, centre Jean-Perrin, université Clermont-Auvergne, 63011 Clermont-Ferrand, France.
          [4 ] Service d'anatomie et cytologie pathologiques, Hôpital Saint-Joseph, 75014 Paris, France.
          Article
          Publisher Item ID: S0242-6498(21)00074-2
          DOI: 10.1016/j.annpat.2021.03.005
          PubMed ID: 33846022
          SO-VID: 81988992-0cc9-49ec-9c26-9d55e66c5798
          History

          Keywords: Targeted therapies,Thérapies ciblées,Fluorescent in situ hybridization,Gene fusions,Gènes de fusion,Hybridation fluorescente in situ,Immunohistochemistry,Immunohistochimie,NTRK,RNA-sequencing,Séquençage des ARN totaux
          Data availability:
          Keywords: Targeted therapies, Thérapies ciblées, Fluorescent in situ hybridization, Gene fusions, Gènes de fusion, Hybridation fluorescente in situ, Immunohistochemistry, Immunohistochimie, NTRK, RNA-sequencing, Séquençage des ARN totaux

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