VGLUT2  rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths

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Abstract

The importance of Vesicular Glutamate Transporter 2 (VGLUT2)-mediated neurotransmission has been highlighted in studies on addiction-related phenotypes. The single nucleotide polymorphism rs2290045 in VGLUT2 has been associated with alcohol dependence, but it is unknown whether or how this association is affected by environmental factors. The present study determined whether the association of alcohol-related problems with the rs2290045 in the VGLUT2 gene was modified by negative and positive environmental factors. Three samples were included: a clinical sample of 131 adolescents followed from age 17 to 22; a general population sample of 1794 young adults; and a general population sample of 1687 adolescents followed from age 14 to 17. DNA was extracted from saliva and the rs2290045 (T/C) was genotyped. Alcohol-related problems were assessed using the Alcohol Use Disorders Identification Test. Stressful life events (SLE) and parenting were assessed by questionnaires. Gene-environment interactions were investigated using a dual statistical approach. In all samples (effect sizes 0.6–6.2%), and consistent with the differential susceptibility framework, T carriers exposed to SLE reported more alcohol-related problems if they had experienced poor parenting, and lower alcohol-related problems if they had received supportive parenting. T carriers not exposed to SLE reported higher alcohol-related problems if they had received supportive parenting and lower alcohol-related problems if they had received poor parenting. Among CC carriers, alcohol-related problems did not vary as a function of negative and positive environmental factors. In conclusion, in three samples of youths, alcohol-related problems were associated with an interaction of VGLUT2 rs2290045, SLE, and parenting.

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Author and article information

Contributors

Erika Comasco:

ORCID: http://orcid.org/0000-0002-2174-2068

+ 46 18 471 50 20 , erika.comasco@neuro.uu.se

Journal

Journal ID (nlm-ta): Eur Child Adolesc Psychiatry

Journal ID (iso-abbrev): Eur Child Adolesc Psychiatry

Title: European Child & Adolescent Psychiatry

Publisher: Springer Berlin Heidelberg (Berlin/Heidelberg )

ISSN (Print): 1018-8827

ISSN (Electronic): 1435-165X

Publication date (Electronic): 25 February 2019

Publication date PMC-release: 25 February 2019

Publication date (Print): 2019

Volume: 28

Issue: 10

Pages: 1329-1340

Affiliations

[1 ]GRID grid.8993.b, ISNI 0000 0004 1936 9457, Department of Neuroscience, Science for Life Laboratory, BMC, , Uppsala University, ; Box 593, 751 24 Uppsala, Sweden

[2 ]GRID grid.8993.b, ISNI 0000 0004 1936 9457, Centre for Clinical Research Västerås, Västmanland County Hospital Västerås, , Uppsala University, ; Uppsala, Sweden

[3 ]GRID grid.15895.30, ISNI 0000 0001 0738 8966, School of Law, Psychology and Social Work, , Örebro University, ; Örebro, Sweden

[4 ]GRID grid.42505.36, ISNI 0000 0001 2156 6853, Department of Psychology, , University of Southern California, ; Los Angeles, USA

[5 ]GRID grid.8993.b, ISNI 0000 0004 1936 9457, Department of Organismal Biology, , Uppsala University, ; Uppsala, Sweden

[6 ]GRID grid.4714.6, ISNI 0000 0004 1937 0626, Department of Clinical Neuroscience, , Karolinska Institutet, ; Stockholm, Sweden

[7 ]GRID grid.14848.31, ISNI 0000 0001 2292 3357, Institut Universitaire en Santé Mentale de Montréal, , Université de Montréal, ; Montreal, Canada

[8 ]GRID grid.8993.b, ISNI 0000 0004 1936 9457, Department of Pharmaceutical Biosciences, , Uppsala University, ; Uppsala, Sweden

Author information

Erika Comasco http://orcid.org/0000-0002-2174-2068

Article

Publisher ID: 1293

DOI: 10.1007/s00787-019-01293-w

PMC ID: 6785645

PubMed ID: 30805764

SO-VID: 81c06a3c-63f6-403a-b070-aecb0b00284e

License:

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.