For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
30
views
15
references
 Top references
cited by
44
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      13
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Macrolide-Resistant Mycoplasma pneumoniae, United States 1

      brief-report

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Macrolide-resistant Mycoplasma pneumoniae (MRMP) is highly prevalent in Asia and is now being reported from Europe. Few data on MRMP are available in the United States. Using genotypic and phenotypic methods, we detected high-level MRMP in 13.2% of 91 M. pneumoniae­–positive specimens from 6 US locations.

          Related collections

          Most cited references15

          • Record: found
          • Abstract: found
          • Article: not found

          The Management of Community-Acquired Pneumonia in Infants and Children Older Than 3 Months of Age: Clinical Practice Guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America

          John Bradley, Carrie L. Byington, Samir S. Shah … (2011)
          Abstract Evidenced-based guidelines for management of infants and children with community-acquired pneumonia (CAP) were prepared by an expert panel comprising clinicians and investigators representing community pediatrics, public health, and the pediatric specialties of critical care, emergency medicine, hospital medicine, infectious diseases, pulmonology, and surgery. These guidelines are intended for use by primary care and subspecialty providers responsible for the management of otherwise healthy infants and children with CAP in both outpatient and inpatient settings. Site-of-care management, diagnosis, antimicrobial and adjunctive surgical therapy, and prevention are discussed. Areas that warrant future investigations are also highlighted.
          Article 0 comments Cited 431 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Rapid effectiveness of minocycline or doxycycline against macrolide-resistant Mycoplasma pneumoniae infection in a 2011 outbreak among Japanese children.

            Kimiko Ubukata, Takafumi Okada, Takeshi Tajima … (2012)
            Mycoplasma pneumoniae is a major pathogen causing community-acquired pneumonia in children and young adults. Outbreaks typically occur at intervals of several years. In 2011, a widespread outbreak was associated with macrolide-resistant M. pneumoniae (MRMP) in Japanese children, often those of school age. Two hundred fifty-eight children were diagnosed with M. pneumoniae-associated pneumonia based on chest radiography, real-time polymerase chain reaction (PCR), and antibody titers between January and December 2011. Mycoplasma pneumoniae cultures obtained from nasopharyngeal samples using appropriate broth were subjected to real-time PCR, by which decreases in M. pneumoniae in patients treated with minocycline (MIN), doxycycline (DOX), or tosufloxacin (TFX) were calculated. Mutations of the 23S ribosomal RNA gene that confer high resistance to macrolides in M. pneumoniae were identified by DNA sequencing. Among 202 M. pneumoniae isolates from M. pneumoniae-associated pneumonia patients, 176 (87.1%) were MRMP. Macrolide-resistant M. pneumoniae infection was significantly related to school age (P < .01) and initial administration of macrolides (P < .01). Minocycline or DOX (n = 125) or TFX or levofloxacin (n = 15) was used for definitive treatment of MRMP patients. Minocycline or DOX was significantly more effective than TFX (P ≤ .05) in achieving defervescence within 24 hours and in decreasing numbers of M. pneumoniae DNA copies 3 days after initiation. Macrolides are inappropriate as first-choice agents against MRMP in terms of shortening the clinical course and decreasing M. pneumoniae. Control and prevention of MRMP outbreaks in children require early decreases in M. pneumoniae as well as improvement of clinical findings.
            Article 0 comments Cited 69 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Macrolide-resistant Mycoplasma pneumoniae: characteristics of isolates and clinical aspects of community-acquired pneumonia.

              Miyuki Morozumi, Kimiko Ubukata, Takashi Takahashi (2010)
              Mycoplasma pneumoniae is one of the main pathogens causing community-acquired respiratory tract infections in children and adults. Macrolide (ML) antibiotics are recognized generally as first-choice agents for M. pneumoniae infections, and these antibiotics were thought to have excellent effectiveness against M. pneumoniae for many years. In 2000, however, M. pneumoniae showing resistance to macrolides was isolated from clinical samples obtained from Japanese pediatric patients with community-acquired pneumonia (CAP). Since then, prevalence of ML-resistant M. pneumoniae isolates in pediatric patients has increased rapidly. In 2007, ML-resistant M. pneumoniae isolates were obtained from Japanese adults with CAP; numbers of such isolates also have gradually increased in Japan. Recently, similar antimicrobial resistance in M. pneumoniae has begun to emerge worldwide. In this review, we focus on changes of ML-resistant M. pneumoniae from year to year and consider resistance mechanisms as well as clinical features of patients with resistant M. pneumoniae infection.
              Article 0 comments Cited 66 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Emerg Infect Dis
                Journal ID (iso-abbrev): Emerging Infect. Dis
                Journal ID (publisher-id): EID
                Title: Emerging Infectious Diseases
                Publisher: Centers for Disease Control and Prevention
                ISSN (Print): 1080-6040
                ISSN (Electronic): 1080-6059
                Publication date (Print): August 2015
                Volume: 21
                Issue: 8
                Pages: 1470-1472
                Affiliations
                [1]Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA (X. Zheng, S. Lee, K. Todd);
                [2]The Children's Mercy Hospitals and Clinics, Kansas City, Missouri, USA (R. Selvarangan);
                [3]Seattle Children’s Hospital, Seattle, Washington, USA (X. Qin);
                [4]Memorial Sloan-Kettering Cancer Center and Weill Medical College of Cornell University, New York, New York, USA (Y.W. Tang, J. Stiles);
                [5]Hackensack University Medical Center, Hackensack, New Jersey, USA (T. Hong);
                [6]University of Alabama at Birmingham, Birmingham, Alabama, USA (A.E. Ratliff, D.M. Crabb, L. Xiao, T.P. Atkinson, K.B. Waites)
                Author notes
                Address for correspondence: Xiaotian Zheng, Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, 225 E Chicago Ave, Box 53, Chicago, IL 60611, USA; email: x-zheng@ 123456northwestern.edu
                Article
                Publisher ID: 15-0273
                DOI: 10.3201/eid2108.150273
                PMC ID: 4517703
                PubMed ID: 26196107
                SO-VID: 82227ff2-4c10-4dfb-bd03-ec6b7fba8a82
                History
                Categories
                Subject: Dispatch
                Subject: Dispatch
                Subject: Macrolide-Resistant Mycoplasma pneumoniae, United States

                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: mycoplasma pneumoniae,macrolide,antimicrobial resistance,mic,united states,children,bacteria
                Data availability:
                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: mycoplasma pneumoniae, macrolide, antimicrobial resistance, mic, united states, children, bacteria

                Comments

                Comment on this article

                scite_

                Similar content13

                See all similar

                Cited by44

                See all cited by

                Most referenced authors148

                See all reference authors