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      Cell cycle, CDKs and cancer: a changing paradigm.

      1 ,
      Nature reviews. Cancer
      Springer Science and Business Media LLC

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          Abstract

          Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as genomic and chromosomal instability. According to current models, mammalian CDKs are essential for driving each cell cycle phase, so therapeutic strategies that block CDK activity are unlikely to selectively target tumour cells. However, recent genetic evidence has revealed that, whereas CDK1 is required for the cell cycle, interphase CDKs are only essential for proliferation of specialized cells. Emerging evidence suggests that tumour cells may also require specific interphase CDKs for proliferation. Thus, selective CDK inhibition may provide therapeutic benefit against certain human neoplasias.

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          Author and article information

          Journal
          Nat Rev Cancer
          Nature reviews. Cancer
          Springer Science and Business Media LLC
          1474-1768
          1474-175X
          Mar 2009
          : 9
          : 3
          Affiliations
          [1 ] Cell Division and Cancer Group, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain.
          Article
          nrc2602
          10.1038/nrc2602
          19238148
          822b3fc8-5511-4798-a00e-f82436fecae4
          History

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