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      Calciphylaxis: risk factors, diagnosis, and treatment.

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          Abstract

          Calciphylaxis is a rare but devastating condition that has continued to challenge the medical community since its early descriptions in the scientific literature many decades ago. It is predominantly seen in patients with chronic kidney failure treated with dialysis (uremic calciphylaxis) but is also described in patients with earlier stages of chronic kidney disease and with normal kidney function. In this review, we discuss the available medical literature regarding risk factors, diagnosis, and treatment of both uremic and nonuremic calciphylaxis. High-quality evidence for the evaluation and management of calciphylaxis is lacking at this time due to its rare incidence and poorly understood pathogenesis and the relative paucity of collaborative research efforts. We hereby provide a summary of recommendations developed by a multidisciplinary team for patients with calciphylaxis.

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          Author and article information

          Journal
          Am. J. Kidney Dis.
          American journal of kidney diseases : the official journal of the National Kidney Foundation
          1523-6838
          0272-6386
          Jul 2015
          : 66
          : 1
          Affiliations
          [1 ] Division of Nephrology, Massachusetts General Hospital, Boston, MA. Electronic address: snigwekar@mgh.harvard.edu.
          [2 ] Department of Dermatology, Massachusetts General Hospital, Boston, MA.
          [3 ] Pathology Service, Dermatopathology Unit, Massachusetts General Hospital, Boston, MA.
          [4 ] Burn Service, Department of Surgery, Massachusetts General Hospital, Boston, MA.
          [5 ] Division of Cardiology, Massachusetts General Hospital, Boston, MA.
          [6 ] Palliative Care Division, Massachusetts General Hospital, Boston, MA.
          [7 ] Division of Nephrology, Massachusetts General Hospital, Boston, MA.
          Article
          S0272-6386(15)00605-8 NIHMS744949
          10.1053/j.ajkd.2015.01.034
          25960299
          8241a5ea-d245-4fcd-a39a-2202b3ffa45e
          Copyright © 2015 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
          History

          Calcific uremic arteriolopathy,calciphylaxis,review,risk factors,sodium thiosulfate,warfarin

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