For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
5
views
49
references
 Top references
cited by
25
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      481
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Treatment of Central Precocious Puberty

      review-article
      Author(s):
      Publication date (Electronic):
      Journal: Journal of the Endocrine Society
      Publisher: Endocrine Society
      Keywords: precocious puberty, treatment, GnRH analogs

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Long-acting analogs of GnRH (GnRHas) have been the gold-standard treatment of central precocious puberty (CPP) worldwide and have an enviable track record of safety and efficacy. Recent years have witnessed much growth in the availability of longer-acting and sustained-release forms of GnRHas. Although all available agents appear promising, limited long-term follow-up and/or comparative data are available. In this review, important issues pertaining to the treatment of children with CPP are discussed. In addition to an assessment of the newer extended-release GnRHa formulations, a delineation of factors essential in determining which children should be treated is offered. Outstanding uncertainties in clinical management are highlighted and areas in need of future research identified. Literature searches for this review were performed in PubMed and OVID, with a focus on English-language publications using the terms “central precocious puberty” and “treatment.”

          Related collections

          Most cited references49

          • Record: found
          • Abstract: found
          • Article: not found

          Precocious puberty and statural growth.

          Jean-Claude Carel, Najiba Lahlou, Marc Roger … (2015)
          Precocious puberty results mostly from the precocious activation of the gonadotropic axis. Although the age limits have recently been discussed, most physicians consider that onset of pubertal development before the age of 8 years in a girl or 9 years in a boy warrants at least a clinical and bone age evaluation by a paediatric endocrinologist. The major concern in precocious puberty is the underlying condition, and central nervous system or gonadal neoplasm have to be formally excluded as a first step in the diagnosis. A secondary concern is height, since precocious puberty leads to accelerated growth, accelerated bone maturation and ultimately reduced stature. Precocious puberty is heterogeneous and strict criteria should be used to define it, both in terms of age and in terms of potential for progression. Depot forms of GnRH agonists are now the standard treatment for progressive central precocious puberty and aim at alleviating the clinical symptoms of early pubertal development, their psychological consequences and the effects on growth. Here, we review the consequences of both central and gonadotropin-independent precocious puberty on adult stature and the information available on outcomes using the therapeutic regimens currently available. In girls with progressive precocious puberty, all published evidence indicates a gain of adult height over height predicted before treatment or over untreated historical controls. However, the apparent height gain (derived from the comparison of predicted and actual heights) is very variable, in large part due to the inaccuracy of height prediction methods. In girls with onset of puberty at the lower half of the normal age (8-10 years) distribution, trials using GnRH agonists have given negative results (no benefit of treatment). In boys, precocious puberty is rare and fewer results are available but point in the same direction. The most appropriate time for interrupting the treatment is still controversial. In conclusion, GnRH agonists restore adult height in children when it is compromised by precocious puberty.
          Article 0 comments Cited 79 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Paternally Inherited DLK1 Deletion Associated With Familial Central Precocious Puberty.

            Andrew Dauber, Marina Cunha-Silva, Delanie B. Macedo … (2017)
            Central precocious puberty (CPP) results from premature activation of the hypothalamic-pituitary-gonadal axis. Few genetic causes of CPP have been identified, with the most common being mutations in the paternally expressed imprinted gene MKRN3.
            Article 0 comments Cited 65 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Hypophysial responses to continuous and intermittent delivery of hypopthalamic gonadotropin-releasing hormone.

              Angus Keogh, E. Knobil, Y Nakai … (1978)
              In rhesus monkeys with hypothalamic lesions that abolish gonadotropic hormone release by the pituitary gland, the constant infusion of exogenous gonadotropin-releasing hormone (GnRH) fails to restore sustained gonadotropin secretion. In marked contrast, intermittent administration of the synthetic decapeptide once per hour, the physiological frequency of gonadotropin release in the monkeys, reestablishes pituitary gonadotropin secretion. This phenomenon is attributable to the pattern of GnRH delivery rather than to the amounts of this hormone to which the cells of the pituitary are exposed. Moreover, the initiation of continuous GnRH administration in animals with lesions and in which gonadotropin secretion is reestablished by intermittent GnRH replacement can result in a "desensitization" or "down regulation" of the processes responsible for gonadotropin release.
              Article 0 comments Cited 56 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Erica A Eugster:
                ORCID: http://orcid.org/0000-0001-6135-7474
                Journal
                Journal ID (nlm-ta): J Endocr Soc
                Journal ID (iso-abbrev): J Endocr Soc
                Journal ID (publisher-id): jes
                Title: Journal of the Endocrine Society
                Publisher: Endocrine Society (Washington, DC )
                ISSN (Electronic): 2472-1972
                Publication date Collection: 01 May 2019
                Publication date (Electronic): 28 March 2019
                Volume: 3
                Issue: 5
                Pages: 965-972
                Affiliations
                [1]Division of Pediatric Endocrinology, Department of Pediatrics, Riley Hospital for Children at Indiana University Health, Indiana University School of Medicine, Indianapolis, Indiana
                Author notes
                Correspondence:  Erica A. Eugster, MD, 705 Riley Hospital Drive, Room 5960, Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana 46202. E-mail: eeugster@ 123456iu.edu .
                Author information
                http://orcid.org/0000-0001-6135-7474
                Article
                Publisher ID: js_201900036
                DOI: 10.1210/js.2019-00036
                PMC ID: 6486823
                PubMed ID: 31041427
                SO-VID: 84353c8b-809c-4da7-b78b-696e3fce3245
                Copyright © Copyright © 2019 Endocrine Society
                License:

                This article has been published under the terms of the Creative Commons Attribution Non-Commercial, No-Derivatives License (CC BY-NC-ND; https://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                Date received : 25 January 2019
                Date accepted : 22 March 2019
                Page count
                Pages: 8
                Categories
                Subject: Mini-Review
                Subject: Reproductive Biology and Sex-Based Medicine

                Keywords: precocious puberty,treatment,gnrh analogs
                Data availability:
                Keywords: precocious puberty, treatment, gnrh analogs

                Comments

                Comment on this article

                scite_

                Similar content481

                See all similar

                Cited by25

                See all cited by

                Most referenced authors536

                See all reference authors