An investigation into the knowledge, perceptions and role of personal protective technologies in Zika prevention in Colombia

Abstract

Background

Arboviruses transmitted by day-biting Aedes mosquitoes are a major public health concern. With the challenges inherent in arbovirus vaccine and therapeutics development, vector control and bite prevention strategies are among the limited options available for immediate intervention. Bite prevention through personal protective technologies (PPT), such as topical mosquito repellents or repellent-impregnated clothing, may help to decrease biting rates and, therefore, the risk of disease in groups most susceptible to adverse outcomes from Zika virus. However, achieving high uptake and compliance with PPT can be challenging.

Methodology/Principal findings

To gain an insight into the knowledge and concerns of pregnant women surrounding Zika and their opinions regarding PPT, particularly repellent clothing, a focus group study was carried out with pregnant women, women of reproductive age, and semi-structured interviews with their male partners in two cities in Colombia. The discussions revealed shortfalls in basic knowledge of Zika virus, with several pregnant participants reporting being unaware of the potential for Zika-related congenital malformations. Although participants generally considered Zika to be a significant personal threat, most rated it as less of a concern than dengue or diarrheal diseases. Overall, repellent clothing and other forms of PPT were viewed as effective, although some participants expressed concerns over the high costs of repellents, and safety fears of regular contact with repellent chemicals, which they perceived as potentially harmful. Plant-derived repellents were considered to be safer than synthetic chemical repellents. Discussions also highlighted that health centers were the preferred source of information on bite-reduction.

Conclusions/Significance

Achieving high uptake and compliance with PPT in populations most at risk of adverse outcomes from Zika infection requires engaging key users in open dialogue to identify and address any practical issues regarding PPT use, and concerns over safety. The findings presented here suggest that educational campaigns should strongly emphasize the risks associated with Zika during pregnancy, and discuss safety profiles of approved synthetic repellents and the availability of EPA-approved plant-based repellents. In addition, the economic and political context should be a major consideration when evaluating personal mosquito-repellent strategies.

Author summary

Although mosquito personal protective technologies (PPT), such as topical DEET or permethrin impregnated clothing, show high efficacy in laboratory studies, they frequently achieve poor population uptake. This is likely due to numerous factors, including high costs, dislike of the feel or smell of the product, and safety fears over the repellent chemicals. The targeted use of PPT to those at elevated risk of severe disease, such as pregnant women in Zika endemic regions, may help mitigate adverse outcomes from Zika virus infection. To explore ways of increasing the appeal of PPT, a focus group study was performed with pregnant women and women of reproductive age in two cities in Colombia. Although almost all participants had heard of Zika, not all pregnant women were aware of the potential for Zika-related birth defects. PPT products were generally viewed as effective, although many expressed fears that repeated exposure to chemicals may affect fetal development. There was limited trust over repellent-manufacturer claims of safety, and women from low socioeconomic groups believed PPT products to be unaffordable. Participants identified health centers as trusted sources of bite-prevention education, suggesting health workers should emphasize safety and efficacy of approved repellents.