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Increased phosphatidylserine-exposing microparticles and their originating cells are associated with the coagulation process in patients with IgA nephropathy.
Zhangxiu He
1 ,
Yan Zhang
2 ,
Muhua Cao
2 ,
Ruishuang Ma
2 ,
Huan Meng
3 ,
Zhipeng Yao
2 ,
Lu Zhao
2 ,
Yan Liu
2 ,
Xiaoming Wu
2 ,
Ruijuan Deng
2 ,
Zengxiang Dong
4 ,
Yayan Bi
4 ,
Junjie Kou
3 ,
Valerie Novakovic
5 ,
Jialan Shi
2 ,
Lirong Hao
1
May 2016
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Abstract
Relatively little information is available about phosphatidylserine positive (PS(+)) microparticles (MPs) and their originating cells in IgA nephropathy (IgAN) despite well-established intraglomerular coagulation. Our objectives were to detect PS exposure on MP membranes and MP-origin cells and to evaluate its role in procoagulant activity (PCA) and fibrin formation and their association with pathological lesions in the disease.