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      Epidemiological trends of leprosy in Goiás, Brasil Translated title: Tendências epidemiológicas da hanseníase em Goiás, Brazil

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          Abstract

          Abstract Brazil is the second nation in absolute number of new cases of leprosy in the world. The country presents many regions highly endemic to the disease, as is the case of the Goiás. The present study aims to analyze the temporal trends of leprosy indicators in Goiás between 2006 and 2015. This study showed a significant trend of decline for the coefficient of detection. Although the central-western region of the state presented the highest absolute number of cases, the Northeast of the state presents the worst epidemiological situation, with an increase in the number of cases of patients with physical disabilities and those under 14 years of age. The data also showed that there is an increase in the cases of patients with physical deformities in almost all macroregions of the state, indicative of late diagnosis. It is very important that there is a more effective and continuous training of the health professionals of the non-centralized units, for a real control of leprosy as a public health problem in the state. In addition, special attention should be given to the poorer regions of the state, which have shown a tendency to increase the diagnosis of patients younger than 14 years and with physical disabilities caused by leprosy.

          Translated abstract

          Resumo O Brasil é a segunda nação em número absoluto de novos casos de hanseníase no mundo. O país apresenta muitas regiões altamente endêmicas para a doença, como é caso do estado de Goiás. O presente estudo tem como objetivo analisar as tendências temporais dos indicadores de hanseníase em Goiás, entre 2006 e 2015. Este estudo demonstrou uma tendência significativa de declínio para o coeficiente de detecção. Embora a macrorregião do Centro-Oeste do estado tenha apresentado a maior ocorrência absoluta de casos, o Nordeste do estado apresenta a pior situação epidemiológica, com aumento no número de casos de pacientes com incapacidades físicas e menores de 14 anos. Os dados mostraram, ainda, que há um aumento nos casos de pacientes com deformidades físicas em quase todas as macrorregiões do estado, indicativo de diagnóstico tardio. É muito importante que haja uma formação mais efetiva e contínua dos profissionais de saúde das unidades não centralizadas, para um controle real da hanseníase como problema de saúde pública no estado. Além disso, uma atenção especial deve ser dada às regiões mais pobres do estado, que apresentaram uma tendência de aumento no diagnóstico de pacientes menores de 14 anos e com incapacidades físicas causadas pela hanseníase.

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          Evidence of hidden leprosy in a supposedly low endemic area of Brazil

          OBJECTIVES Show that hidden endemic leprosy exists in a municipality of inner São Paulo state (Brazil) with active surveillance actions based on clinical and immunological evaluations. METHODS The study sample was composed by people randomly selected by a dermatologist during medical care in the public emergency department and by active surveillance carried out during two days at a mobile clinic. All subjects received a dermato-neurological examination and blood sampling to determine anti-PGL-I antibody titers by enzyme-linked immunosorbent assay (ELISA). RESULTS From July to December 2015, 24 new cases of leprosy were diagnosed; all were classified as multibacillary (MB) leprosy, one with severe Lucio's phenomenon. Seventeen (75%) were found with grade-1 or 2 disability at the moment of diagnosis. Anti-PGL-I titer was positive in 31/133 (23.3%) individuals, only 6/24 (25%) were positive in newly diagnosed leprosy cases. CONCLUSIONS During the last ten years before this study, the average new case detection rate (NCDR) in this town was 2.62/100,000 population. After our work, the NCDR was raised to 42.8/100,000. These results indicate a very high number of hidden leprosy cases in this supposedly low endemic area of Brazil.
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            Spatial patterns of leprosy in a hyperendemic state in Northern Brazil, 2001-2012

            ABSTRACT OBJECTIVE To describe the spatial patterns of leprosy in the Brazilian state of Tocantins. METHODS This study was based on morbidity data obtained from the Sistema de Informações de Agravos de Notificação (SINAN – Brazilian Notifiable Diseases Information System), of the Ministry of Health. All new leprosy cases in individuals residing in the state of Tocantins, between 2001 and 2012, were included. In addition to the description of general disease indicators, a descriptive spatial analysis, empirical Bayesian analysis and spatial dependence analysis were performed by means of global and local Moran’s indexes. RESULTS A total of 14,542 new cases were recorded during the period under study. Based on the annual case detection rate, 77.0% of the municipalities were classified as hyperendemic (> 40 cases/100,000 inhabitants). Regarding the annual case detection rate in < 15 years-olds, 65.4% of the municipalities were hyperendemic (10.0 to 19.9 cases/100,000 inhabitants); 26.6% had a detection rate of grade 2 disability cases between 5.0 and 9.9 cases/100,000 inhabitants. There was a geographical overlap of clusters of municipalities with high detection rates in hyperendemic areas. Clusters with high disease risk (global Moran’s index: 0.51; p < 0.001), ongoing transmission (0.47; p < 0.001) and late diagnosis (0.44; p < 0.001) were identified mainly in the central-north and southwestern regions of Tocantins. CONCLUSIONS We identified high-risk clusters for transmission and late diagnosis of leprosy in the Brazilian state of Tocantins. Surveillance and control measures should be prioritized in these high-risk municipalities.
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              Operacionalizando as categorias acesso e descentralização na análise de sistemas de saúde

              O artigo apresenta proposta de operacionalização das categorias acesso e descentralização em modelo de análise de sistemas de saúde. Admite a hipótese de que se o sistema de saúde é descentralizado, ele vai permitir maior acesso dos usuários ao sistema. Pretende-se com essa proposta contribuir com uma maior vinculação dessas categorias na realidade observada.
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                Author and article information

                Journal
                csc
                Ciência & Saúde Coletiva
                Ciênc. saúde coletiva
                ABRASCO - Associação Brasileira de Saúde Coletiva (Rio de Janeiro, RJ, Brazil )
                1413-8123
                1678-4561
                October 2020
                : 25
                : 10
                : 3723-3730
                Affiliations
                [2] Anápolis Goiás orgnameUniversidade Estadual de Goiás orgdiv1Programa de Ciências Aplicadas a Produtos para Saúde Brazil
                [3] Anápolis GO orgnameUEG orgdiv1Programa de Recursos Naturais do Cerrado Brazil
                [1] Goiânia Goiás orgnameUniversidade Federal de Goiás orgdiv1Faculdade de Medicina Brazil camilamufg@ 123456gmail.com
                Article
                S1413-81232020001103723 S1413-8123(20)02501003723
                10.1590/1413-812320202510.31022018
                8515213e-9a6d-4fd4-a503-b97f724694e5

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                : 06 August 2018
                : 18 December 2018
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 29, Pages: 8
                Product

                SciELO Public Health

                Categories
                Article

                Public health,Endemic diseases,Descentralização,Estudos de séries temporais,Doenças endêmicas,Saúde pública,Decentralization,Time series studies

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