Makhosazane Zungu-Edmondson: Role: InvestigationRole: MethodologyRole: Writing – original draftRole: Writing –
review & editing
Nataliia V. Shults: Role: Formal analysisRole: InvestigationRole: MethodologyRole: Writing – original
draftRole: Writing – review & editing
Oleksiy Melnyk: Role: InvestigationRole: Writing – review & editing
Yuichiro J. Suzuki:
ORCID: http://orcid.org/0000-0001-6689-0497
Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole:
MethodologyRole: Project administrationRole: SupervisionRole: Writing – original draftRole:
Writing – review & editing
You-Yang Zhao: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
15
August
2017
Publication date Collection: 2017
Volume: 12
Issue: 8
Electronic Location Identifier: e0182551
Affiliations
[001]Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington,
DC, United States of America
University of Illinois at Chicago College of Medicine, UNITED STATES
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-17-09298
DOI: 10.1371/journal.pone.0182551
PMC ID: 5557492
PubMed ID: 28809956
SO-VID: 85b9ce88-0161-4c3d-8ad8-1eb3bd946f0e
Copyright © © 2017 Zungu-Edmondson et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/100000050, National Heart, Lung, and Blood Institute;
Award ID: R01HL72844
Award Recipient
:
ORCID: http://orcid.org/0000-0001-6689-0497
Yuichiro J. Suzuki
Funded by: funder-id http://dx.doi.org/10.13039/100000049, National Institute on Aging;
Award ID: R03AG047824
Award Recipient
:
ORCID: http://orcid.org/0000-0001-6689-0497
Yuichiro J. Suzuki
This work is supported by National Institutes of Health (R01HL72844 and R03AG047824).
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Metabolism
Subject:
Metabolomics
Subject:
Biology and Life Sciences
Subject:
Developmental Biology
Subject:
Fibrosis
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Blood Vessels
Subject:
Arteries
Subject:
Pulmonary Arteries
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Blood Vessels
Subject:
Arteries
Subject:
Pulmonary Arteries
Subject:
Research and Analysis Methods
Subject:
Database and Informatics Methods
Subject:
Database Searching
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Collagens
Subject:
Medicine and Health Sciences
Subject:
Pulmonology
Subject:
Medical Hypoxia
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Connective Tissue Cells
Subject:
Fibroblasts
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Connective Tissue Cells
Subject:
Fibroblasts
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Connective Tissue Cells
Subject:
Fibroblasts
Subject:
Research and analysis methods
Subject:
Experimental organism systems
Subject:
Model organisms
Subject:
Rats
Subject:
Sprague-Dawley rats
Subject:
Research and analysis methods
Subject:
Model organisms
Subject:
Rats
Subject:
Sprague-Dawley rats
Subject:
Research and analysis methods
Subject:
Experimental organism systems
Subject:
Animal models
Subject:
Rats
Subject:
Sprague-Dawley rats
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Mammals
Subject:
Rodents
Subject:
Rats
Subject:
Sprague-Dawley rats