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Abstract
Retinopathy of prematurity(ROP) is the most common serious ophthalmic disease in preterm
infants. Human milk may provide a protective effect for ROP; however, beneficial effects
of human milk preclude randomized trials. Therefore, we conducted a retrospective
analysis comparing early postnatal nutrition with ROP development.
Evaluate relationship between early postnatal nutriture and ROP surgery.
Nutrition data was collected for inborn AGA infants, BW 700-1000 g. ROP surgery was
the primary outcome variable. A single pediatric ophthalmologist supervised examinations.
All infants received triweekly IM vitamin A as chronic lung disease prophylaxis (Tyson:
NEJM, 1999).
BW and gestational age were 867+/-85 g and 26.3+/-1.2 weeks (n=77, mean+/-1SD). ROP
surgery infants(n=11) received more parenteral nutrition, 1648 mL, and less human
milk, 13.8 mL/kg-day, and vitamin E, 1.4 mg/kg-day, during the second postnatal week.
Human milk was a negative predictor for ROP surgery, odds ratio=0.94. Both groups
met vitamin A recommendations; however, 74% was administered via IM injections. Neither
group met vitamin E recommendations.
Human milk feeding, parenteral nutrition volume and vitamin E intake were predictors
for ROP surgery. IM vitamin A injections provided the majority of vitamin A; vitamin
E administration was insufficient. Improving human milk feeding rates and vitamin
dosing options may affect ROP surgery rates.
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