Manuel Zeitelhofer: Role: InvestigationRole: Writing – original draft
Hong Li: Role: InvestigationRole: Writing – original draft
Milena Z. Adzemovic: Role: Investigation
Ingrid Nilsson: Role: Investigation
Lars Muhl: Role: Investigation
Andrew M. Scott: Role: SupervisionRole: Writing – review & editing
Ulf Eriksson:
ORCID: http://orcid.org/0000-0002-4439-3980
Role: ConceptualizationRole: SupervisionRole: Writing – review & editing
Salvatore V Pizzo: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
18
July
2018
Publication date Collection: 2018
Volume: 13
Issue: 7
Electronic Location Identifier: e0200649
Affiliations
[1
]
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm,
Sweden
[2
]
Olivia Newton-John Cancer Research Institute, and School of Cancer Medicine, La Trobe
University, Melbourne, Australia
Duke University School of Medicine, UNITED STATES
Author notes
Competing Interests: H.L., A.M.S. and U.E. have submitted a patent application (Methods and compositions
for PDGF-CC inhibition, PCT/US2017/040170) on these antibodies. A.M.S. and U.E. are
shareholders of a company (Paracrine Therapeutics AB) developing these antibodies.
This does not alter our adherence to PLOS ONE policies on sharing data and materials.
Author information
Article
Publisher ID:
PONE-D-18-06318
DOI: 10.1371/journal.pone.0200649
PMC ID: 6051635
PubMed ID: 30021009
SO-VID: 86f852fc-ac0e-4793-ab89-c63fb8a2ebc9
Copyright © © 2018 Zeitelhofer et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: Australian National Health and Medical Research Council (NHMRC)
Award ID: 1038334 and 1075898
Award Recipient
:
Andrew M. Scott
Funded by: The Swedish Heart and Lung Foundation
Award ID: 20110451, 20120077
Award Recipient
:
ORCID: http://orcid.org/0000-0002-4439-3980
Ulf Eriksson
Funded by: The Swedish Research Council
Award ID: 2011-03861,2016-02593,2017-00691
Award Recipient
:
ORCID: http://orcid.org/0000-0002-4439-3980
Ulf Eriksson
Funded by: The Swedish Cancer Foundation
Award ID: CAN2016/633,CAN2014/630
Award Recipient
:
ORCID: http://orcid.org/0000-0002-4439-3980
Ulf Eriksson
Funded by: funder-id http://dx.doi.org/10.13039/501100004047, Karolinska Institutet;
Award Recipient
:
ORCID: http://orcid.org/0000-0002-4439-3980
Ulf Eriksson
This study was supported by the Swedish Heart and Lung Foundation (20110451 and 20120077,
U.E.), the Swedish Research Council (2011-03861, 2016-02593, 2017-00691, U.E.), Cancerfonden
(CAN 2016/633, CAN 2014/630, U.E.), Karolinska Institutet, the Australian National
Health and Medical Research Council (NHMRC) Development Grants (1038334 and 1075898,
A.M.S.), the Practitioner Fellowship (A.M.S.) and funds from the Operational Infrastructure
Support Program provided by the Victorian Government, Australia. The funders provided
support in the form of salaries for authors [HL, MZ, IN, LM, AMS and UE], but did
not have any additional role in the study design, data collection and analysis, decision
to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Research and Analysis Methods
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Mouse Models
Subject:
Medicine and Health Sciences
Subject:
Hematology
Subject:
Medicine and Health Sciences
Subject:
Neurology
Subject:
Cerebrovascular Diseases
Subject:
Stroke
Subject:
Ischemic Stroke
Subject:
Medicine and Health Sciences
Subject:
Vascular Medicine
Subject:
Stroke
Subject:
Ischemic Stroke
Subject:
Biology and Life Sciences
Subject:
Toxicology
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Toxicology
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Mutation
Subject:
Point Mutation
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Mutation
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Renal System
Subject:
Kidneys
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Renal System
Subject:
Kidneys
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Spleen
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Spleen