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      Study on essential drug use status and its influencing factors among cerebral infarction inpatients in county level hospitals of Anhui Province, China

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          Abstract

          Background and purpose

          Drug costs is one of the main components of hospitalization expenditure for cerebral infarction inpatients. In China, the National Essential Medicine System (NEMS) was created to relieve the heavy drug-cost burden for patients. The objective of this study was to investigate essential drug-use status and its influencing factors among cerebral infarction inpatients in county-level hospitals of Anhui province, China.

          Methods

          Three county-level hospitals were selected through a multi-stage cluster random sampling method. The hospitalization cost data of cerebral infarction inpatients in the three hospitals were extracted from the Anhui provincial information platform of the New Rural Cooperative Insurance System (NCMS), and whether the proportion of essential drug cost in the total drug cost reached the median value of 33.05% which was set as the evaluation index for essential drug-use status. Questionnaires for hospitals and physicians were designed and given to them to assess influencing factors.

          Results

          We retrieved the cost data of 2,189 inpatients from the NCMS platform and investigated 51 corresponding physicians in total. The drug costs accounted for 52.6% of the total hospitalization cost, and essential drug costs alone accounted for 37.0% of the total drug costs. The essential drug-cost proportion was high among physicians with a higher recognition degree on NEMS, older age, lower final academic degree, longer work experience and lower professional title. Married physicians and those with tight organizational affiliation also prescribed more essential drugs.

          Conclusions

          Increasing the proportion of essential drugs was an effective way to reduce the disease burden for cerebral infarction patients. Perfecting the NEMS, increasing government investment, reinforcing education and propaganda, and formulating relevant incentive and restrictive mechanisms were all effective ways to promote and increase the number of essential drug prescriptions written by physicians.

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          Most cited references32

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          The impact of the National Essential Medicines Policy on prescribing behaviours in primary care facilities in Hubei province of China.

          To assess the impact of the National Essential Medicines Policy (NEMP) on the use of medicines in government-owned primary care institutions in Hubei province of China. Quasi-experimental design and time-trend analysis. A systematic random sampling strategy was employed to select 55,800 prescriptions from 18 primary care organizations who progressively implemented the NEMP from January 2009 to July 2011. We examined the change of patterns of prescriptions. The facilities that implemented the NEMP at a later stage served as control. An immediate increased uptake of essential medicines of all drugs prescribed which ultimately neared 95%. In total, 38,151 prescriptions (68%) involved antibiotics, and we found no evidence of reduction after the NEMP interventions. A high percentage (59-66%) of prescription drugs were administered through parenteral routes and no reduction was found after the NEMP interventions. Although the average number of medicines per prescription remained unchanged (nearly four), the average cost per prescription declined significantly after the NEMP interventions (¥ 44.67 vs ¥ 26.67 CNY, P < 0.03). The NEMP interventions reduced the average cost per prescription; however, the irrational use of antibiotics and unnecessary parenteral administration remains prevalent. The goals of the NEMP are partially achieved; we therefore recommend a strategic approach involving all stakeholders to comprehensively achieve all aspirations.
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            Evaluation, in three provinces, of the introduction and impact of China's National Essential Medicines Scheme

            OBJECTIVE: To evaluate implementation of the National Essential Medicines Scheme (NEMS) in rural China. METHODS: Two rural counties/districts in each of three provinces where NEMS had been implemented were surveyed. Information was collected from NEMS staff at the province, county/district, township and village levels; patients with chronic disease were also interviewed. Service provision, finances, prescriptions, inpatient records and the expenditures of patients with certain diagnoses were investigated in township hospitals and village clinics. The results were compared with the corresponding data recorded before NEMS was introduced. FINDINGS: Following the introduction of NEMS, drug procurement in each study location was systematized. Total drug costs declined. This, and improved prescribing, reduced the costs of outpatient and inpatient care and led, apparently, to increased uptake of health services. However, the prices of some drugs had increased and the availability of others had declined. The compensation of health-care providers for NEMS-related reductions in their incomes had been largely ineffective. As a result of the introduction of NEMS, health facilities relied more on public financing. Many health-care providers complained about higher workloads and lower incomes. CONCLUSION: Although it was well conceived, the introduction of NEMS into China's decentralized, fee-for-service system of health care has not been straightforward. It has highlighted the problems associated with attempts to modernize health care and health financing for patients' benefit. Sustainable mechanisms to compensate health-care providers for lost income are needed to ensure that NEMS is a success.
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              Association of cardiovascular health screening with mortality, clinical outcomes, and health care cost: a nationwide cohort study.

              To determine whether a cardiovascular disease (CVD) health screening program is associated with CVD-related health conditions, incidence of cardiovascular events, mortality, healthcare utilization, and costs.
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                Author and article information

                Contributors
                Role: Data curationRole: Investigation
                Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draftRole: Writing – review & editing
                Role: ConceptualizationRole: Data curationRole: Funding acquisitionRole: MethodologyRole: Project administrationRole: SupervisionRole: ValidationRole: Writing – review & editing
                Role: Data curationRole: Investigation
                Role: Data curationRole: Formal analysisRole: Investigation
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                5 April 2018
                2018
                : 13
                : 4
                : e0193513
                Affiliations
                [1 ] Social Science and Health Management School, Anhui Medical University, Hefei, China
                [2 ] Department of Research Administration, The First Affiliated Hospital of Anhui Medical University, Hefei, China
                [3 ] Department of Deam’s Office, The First Affiliated Hospital of Anhui Medical University, Hefei, China
                [4 ] Department of Human Resources, The First Affiliated Hospital of Anhui Medical University, Hefei, China
                Karolinska Institutet, SWEDEN
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                ‡ These authors are co-first authors on this work.

                Author information
                http://orcid.org/0000-0003-4668-0075
                Article
                PONE-D-17-21246
                10.1371/journal.pone.0193513
                5886397
                29621245
                8704f081-3f21-4344-978a-6b1c128062d7
                © 2018 Wang et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 15 June 2017
                : 6 February 2018
                Page count
                Figures: 0, Tables: 5, Pages: 12
                Funding
                Funded by: the National Science Foundation of China
                Award ID: 71473003
                Award Recipient :
                Funded by: the National Science Foundation of China
                Award ID: 71774001
                Award Recipient :
                Funded by: Young’s Culture Plan of the First Affiliated Hospital of Anhui Medical University
                Award ID: 2015kj10
                Award Recipient :
                This research was supported by grants from the National Science Foundation of China (No. 71473003; No. 71774001 Received by HW) and Young’s Culture Plan of the First Affiliated Hospital of Anhui Medical University (No. 2015kj10; Received by NL). The URL of the National Science Foundation of China is http://www.nsfc.gov.cn/. The URL of the latter funder is http://www.ayfy.com/menhuweb/show.php?itemid=7555. Neither of the above two funders had role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
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