A Comprehensive Survey of Digital Twins in Healthcare in the Era of Metaverse

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Abstract

Digital twins (DTs) are becoming increasingly popular in various industries, and their potential for healthcare in the metaverse continues to attract attention. The metaverse is a virtual world where individuals interact with digital replicas of themselves and the environment. This paper focuses on personalized and precise medicine and examines the current application of DTs in healthcare within the metaverse. Healthcare practitioners may use immersive virtual worlds to replicate medical scenarios, improve teaching experiences, and provide personalized care to patients. However, the integration of DTs in the metaverse poses technical, regulatory, and ethical challenges that need to be addressed, including data privacy, standards, and accessibility. Through this examination, we aim to provide insights into the transformative potential of DTs in healthcare within the metaverse and encourage further research and development in this exciting domain.

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MIMIC-III, a freely accessible critical care database

Alistair E.W. Johnson, Tom J. Pollard, Lu Shen … (2016)

MIMIC-III (‘Medical Information Mart for Intensive Care’) is a large, single-center database comprising information relating to patients admitted to critical care units at a large tertiary care hospital. Data includes vital signs, medications, laboratory measurements, observations and notes charted by care providers, fluid balance, procedure codes, diagnostic codes, imaging reports, hospital length of stay, survival data, and more. The database supports applications including academic and industrial research, quality improvement initiatives, and higher education coursework.

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The healthy human microbiome

Jason Lloyd-Price, Galeb Abu-Ali, Curtis Huttenhower (2016)

Humans are virtually identical in their genetic makeup, yet the small differences in our DNA give rise to tremendous phenotypic diversity across the human population. By contrast, the metagenome of the human microbiome—the total DNA content of microbes inhabiting our bodies—is quite a bit more variable, with only a third of its constituent genes found in a majority of healthy individuals. Understanding this variability in the “healthy microbiome” has thus been a major challenge in microbiome research, dating back at least to the 1960s, continuing through the Human Microbiome Project and beyond. Cataloguing the necessary and sufficient sets of microbiome features that support health, and the normal ranges of these features in healthy populations, is an essential first step to identifying and correcting microbial configurations that are implicated in disease. Toward this goal, several population-scale studies have documented the ranges and diversity of both taxonomic compositions and functional potentials normally observed in the microbiomes of healthy populations, along with possible driving factors such as geography, diet, and lifestyle. Here, we review several definitions of a ‘healthy microbiome’ that have emerged, the current understanding of the ranges of healthy microbial diversity, and gaps such as the characterization of molecular function and the development of ecological therapies to be addressed in the future.