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      Dehydroepiandrosterone Sulfate and Growth Axis Hormones in Patients with Ischemic Heart Disease

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          Background: The present study aimed to determine whether decreases in dehydroepiandrosterone sulfate (DHEA-S) and growth axis components precede cardiovascular disease or are a consequence of it. Methods: We measured the concentrations in serum of DHEA-S, ACTH, cortisol, growth hormone, insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 in 30 male controls and also in 37 male patients on days 0, 2, 5, 7 and 9 after suffering a myocardial infarction (MI). Results: There was no significant variation in any of these parameters between the controls and the patients on day 0. However, we found a significant (p < 0.001) reduction in the DHEA-S concentrations of the patients between day 0 and subsequent days (days 2, 5, 7and 9). Conclusion: We conclude that the decrease in DHEA-S in patients with MI is a consequence and not a cause of the disease.

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          Most cited references 1

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          Growth hormone and the heart

           L Saccà (1994)

            Author and article information

            Horm Res Paediatr
            Hormone Research in Paediatrics
            S. Karger AG
            30 May 2002
            : 57
            : 5-6
            : 165-169
            Department of Biochemistry and Molecular Biology, Clínico Hospital, University of Granada, Spain
            58377 Horm Res 2002;57:165–169
            © 2002 S. Karger AG, Basel

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            Page count
            Figures: 3, Tables: 1, References: 25, Pages: 5
            Original Paper


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