5-Azo(4'-substituted benzenesulphamoyl)-8-hydroxyquinolines(III) have been prepared
by coupling of the appropriate p-substituted benzenesulphamoyldiazonium acetates with
8-hydroxyquinoline. The corresponding copper chelates(IV) and iron chelates(V) were
also prepared in a 1:2 metal to ligand ratio. Structures of III, IV and V were confirmed
by some representative UV, IR, and NMR spectrometry in addition to microanalysis.
Antidotal activity of four ligands (IIIa, IIId, IIIf, and IIIi) has been evaluated
in mice against the toxicity of lead acetate and copper sulphate. Study revealed that
compound IIIf elicited significant antidotal activity against lead and copper poisoning,
while IIIi was potent only against lead poisoning. Antibacterial activity of compounds
III, IV, and V was also determined in comparison to sulphanilamide against Staph.
aureus, Bacill. cereus, and Esch. coli. The test compounds showed variable bacteriostatic
activities, and some of them (IIIc, IIId, IIIf, Ve, IIIg, and Vi) are more effective
than the reference drug, especially against Bacill. cereus.