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Depression
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Abstract
Major depression is a common illness that severely limits psychosocial functioning
and diminishes quality of life. In 2008, WHO ranked major depression as the third
cause of burden of disease worldwide and projected that the disease will rank first
by 2030.1 In practice, its detection, diagnosis, and management often pose challenges
for clinicians because of its various presentations, unpredictable course and prognosis,
and variable response to treatment.