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      Parathyroid Cancer: A Review

      review-article
      Author(s): 1 , 2 , *
      Publication date (Electronic):
      Journal: Cancers
      Publisher: MDPI
      Keywords: parathyroid cancer, epidemiology, diagnosis, surgical management, surveillance

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          Abstract

          Parathyroid cancer is one of the rarest causes of primary hyperparathyroidism and tends to present with more severe symptoms than its more benign counterparts. This article details various aspects of the disease process, including epidemiology, clinical presentation, and a step-wise diagnostic process for parathyroid cancer. This includes laboratory assessments as well as a proposed staging system. The en bloc principle of surgical intervention is detailed, as well as the current role of adjuvant treatments. A general guide to surveillance and the natural history of the disease is also outlined.

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          Hyperparathyroidism

          William Fraser (2009)
          The Lancet, 374(9684), 145-158
          Article 0 comments Cited 220 times – based on 0 reviews     Review now
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            HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome.

            Catharina Larsson, L Forsberg, Nancy Perrier … (2002)
            We report here the identification of a gene associated with the hyperparathyroidism-jaw tumor (HPT-JT) syndrome. A single locus associated with HPT-JT (HRPT2) was previously mapped to chromosomal region 1q25-q32. We refined this region to a critical interval of 12 cM by genotyping in 26 affected kindreds. Using a positional candidate approach, we identified thirteen different heterozygous, germline, inactivating mutations in a single gene in fourteen families with HPT-JT. The proposed role of HRPT2 as a tumor suppressor was supported by mutation screening in 48 parathyroid adenomas with cystic features, which identified three somatic inactivating mutations, all located in exon 1. None of these mutations were detected in normal controls, and all were predicted to cause deficient or impaired protein function. HRPT2 is a ubiquitously expressed, evolutionarily conserved gene encoding a predicted protein of 531 amino acids, for which we propose the name parafibromin. Our findings suggest that HRPT2 is a tumor-suppressor gene, the inactivation of which is directly involved in predisposition to HPT-JT and in development of some sporadic parathyroid tumors.
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              Clinical review 122: Parathyroid carcinoma.

              E Shane (2001)
              Article 0 comments Cited 101 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Cancers (Basel)
                Journal ID (iso-abbrev): Cancers (Basel)
                Journal ID (publisher-id): cancers
                Title: Cancers
                Publisher: MDPI
                ISSN (Electronic): 2072-6694
                Publication date (Electronic): 28 October 2019
                Publication date Collection: November 2019
                Volume: 11
                Issue: 11
                Electronic Location Identifier: 1676
                Affiliations
                [1 ]Department of Surgery, University Hospitals Conneaut, Conneaut, OH 44030, USA; nikita.n.machado@ 123456gmail.com
                [2 ]Department of Surgery, Endocrine Surgery, University Hospitals Cleveland, University Hospitals, Cleveland, OH 44106, USA
                Author notes
                [* ]Correspondence: scott.wilhelm@ 123456uhhospitals.org ; Tel.: +216-844-8283
                Article
                Publisher ID: cancers-11-01676
                DOI: 10.3390/cancers11111676
                PMC ID: 6896123
                PubMed ID: 31661917
                SO-VID: 8a6ad807-4c08-49d8-a049-221532321dfe
                Copyright © © 2019 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 12 September 2019
                Date accepted : 25 October 2019
                Categories
                Subject: Review

                Keywords: parathyroid cancer,epidemiology,diagnosis,surgical management,surveillance
                Data availability:
                Keywords: parathyroid cancer, epidemiology, diagnosis, surgical management, surveillance

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