Curcumin inhibition of Dermatophagoides farinea-induced interleukin-5 (IL-5) and granulocyte macrophage-colony stimulating factor (GM-CSF) production by lymphocytes from bronchial asthmatics
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Abstract
Curcumin, a dietary pigment responsible for the yellow color of curry, has been used
for the treatment of inflammatory diseases and exhibits a variety of pharmacological
effects such as anti-inflammatory, anti-tumor, anti-oxidant, and anti-viral activity.
However, it has not been determined whether the effect of curcumin on the production
of cytokine affects eosinophil functions and IgE synthesis. In the present study,
we examined the effect of curcumin on the production of interleukin (IL)-2, IL-5,
granulocyte macrophage-colony stimulating factor (GM-CSF), and IL-4 by lymphocytes
from atopic asthmatics in response to house dust mites (Dermatophagoides farinea:
Df) in order to clarify a potential application for allergic diseases. Curcumin inhibited
Df-induced lymphocyte proliferation and production of IL-2. Exogenous IL-2 reconstituted
the proliferative responsiveness of lymphocytes to Df in the presence of curcumin.
Furthermore, curcumin inhibited IL-5, GM-CSF, and IL-4 production in a concentration-dependent
manner. These results indicate that curcumin may have a potential effect on controlling
allergic diseases through inhibiting the production of cytokines affecting eosinophil
function and IgE synthesis.