Conversion of Thyroxine to Triiodothyronine and Reverse Triiodothyronine in Human Placenta and Fetal Membranes

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Abstract

Conversion of thyroxine (T4) to 3,5,3’-triiodothyronine (T3) and reverse 3,3’,5’-triiodothyronine (rT3) was measured in vitro in human placenta and fetal membranes. T4 (5 µg/ml) was incubated in 0.15 mol/l phosphate buffer with tissue homogenates for 2 h at 37°C, and the T3 and rT3 generated were determined in ethanol extract using RIA methods. The placenta and chorion homogenates converted more T4 to T3 than to rT3; the placenta was more active than the chorion. In both tissues the highest converting activity was found in microsomal fractions.

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Author and article information

Journal

Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1980

Publication date (Print): 1980

Publication date (Electronic): 25 November 2008

Volume: 12

Issue: 5

Pages: 253-259

Affiliations

Department of Medicine, Clinical Hospital, Zagreb

Article

Publisher ID: 179128 Other ID: Horm Res 1980;12:253–259

DOI: 10.1159/000179128

PubMed ID: 7399397

SO-VID: 8ae7bf01-ab1d-4e3d-b5cf-d3622048925e

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 20 September 1979

Date accepted : 05 January 1980

Page count

Pages: 7

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