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      Two Similarity Metrics for Medical Subject Headings (MeSH): : An Aid to Biomedical Text Mining and Author Name Disambiguation

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          Abstract

          In the present paper, we have created and characterized several similarity metrics for relating any two Medical Subject Headings (MeSH terms) to each other. The article-based metric measures the tendency of two MeSH terms to appear in the MEDLINE record of the same article. The author-based metric measures the tendency of two MeSH terms to appear in the body of articles written by the same individual (using the 2009 Author-ity author name disambiguation dataset as a gold standard). The two metrics are only modestly correlated with each other (r = 0.50), indicating that they capture different aspects of term usage. The article-based metric provides a measure of semantic relatedness, and MeSH term pairs that co-occur more often than expected by chance may reflect relations between the two terms. In contrast, the author metric is indicative of how individuals practice science, and may have value for author name disambiguation and studies of scientific discovery. We have calculated article metrics for all MeSH terms appearing in at least 25 articles in MEDLINE (as of 2014) and author metrics for MeSH terms published as of 2009. The dataset is freely available for download and can be queried at http://arrowsmith.psych.uic.edu/arrowsmith_uic/mesh_pair_metrics.html. Handling editor: Elizabeth Workman, MLIS, PhD.

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          Mapping the backbone of science

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            Measures of semantic similarity and relatedness in the biomedical domain.

            Measures of semantic similarity between concepts are widely used in Natural Language Processing. In this article, we show how six existing domain-independent measures can be adapted to the biomedical domain. These measures were originally based on WordNet, an English lexical database of concepts and relations. In this research, we adapt these measures to the SNOMED-CT ontology of medical concepts. The measures include two path-based measures, and three measures that augment path-based measures with information content statistics from corpora. We also derive a context vector measure based on medical corpora that can be used as a measure of semantic relatedness. These six measures are evaluated against a newly created test bed of 30 medical concept pairs scored by three physicians and nine medical coders. We find that the medical coders and physicians differ in their ratings, and that the context vector measure correlates most closely with the physicians, while the path-based measures and one of the information content measures correlates most closely with the medical coders. We conclude that there is a role both for more flexible measures of relatedness based on information derived from corpora, as well as for measures that rely on existing ontological structures.
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              Is Open Access

              Clustering More than Two Million Biomedical Publications: Comparing the Accuracies of Nine Text-Based Similarity Approaches

              Background We investigate the accuracy of different similarity approaches for clustering over two million biomedical documents. Clustering large sets of text documents is important for a variety of information needs and applications such as collection management and navigation, summary and analysis. The few comparisons of clustering results from different similarity approaches have focused on small literature sets and have given conflicting results. Our study was designed to seek a robust answer to the question of which similarity approach would generate the most coherent clusters of a biomedical literature set of over two million documents. Methodology We used a corpus of 2.15 million recent (2004-2008) records from MEDLINE, and generated nine different document-document similarity matrices from information extracted from their bibliographic records, including titles, abstracts and subject headings. The nine approaches were comprised of five different analytical techniques with two data sources. The five analytical techniques are cosine similarity using term frequency-inverse document frequency vectors (tf-idf cosine), latent semantic analysis (LSA), topic modeling, and two Poisson-based language models – BM25 and PMRA (PubMed Related Articles). The two data sources were a) MeSH subject headings, and b) words from titles and abstracts. Each similarity matrix was filtered to keep the top-n highest similarities per document and then clustered using a combination of graph layout and average-link clustering. Cluster results from the nine similarity approaches were compared using (1) within-cluster textual coherence based on the Jensen-Shannon divergence, and (2) two concentration measures based on grant-to-article linkages indexed in MEDLINE. Conclusions PubMed's own related article approach (PMRA) generated the most coherent and most concentrated cluster solution of the nine text-based similarity approaches tested, followed closely by the BM25 approach using titles and abstracts. Approaches using only MeSH subject headings were not competitive with those based on titles and abstracts.
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                Author and article information

                Journal
                J Biomed Discov Collab
                J Biomed Discov Collab
                J Biomed Discov
                Journal of Biomedical Discovery and Collaboration
                University of Illinois at Chicago Library
                1747-5333
                15 April 2016
                2016
                : 7
                : e1
                Affiliations
                [1]Department of Psychiatry, University of Illinois at Chicago, 1601 W. Taylor Street MC912, Chicago, IL 60612 USA
                Author notes
                [* ]Correspondence: neils@ 123456uic.edu
                Article
                Jbiomeddiscovcollab-07-e01
                10.5210/disco.v7i0.6654
                4845330
                27213780
                8bb4c187-f24a-4d4b-8b56-ef76a904e8fb
                This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
                History
                Categories
                Research Article

                Medicine
                scientometrics,authorship,scientific publication,medline,interdisciplinarity,text mining,author name disambiguation,scientific journals,bibliometrics,discovery,novelty

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