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      RNAi therapeutics: principles, prospects and challenges.

      Advanced Drug Delivery Reviews

      Animals, Humans, Models, Biological, Nanoparticles, chemistry, Neoplasms, genetics, therapy, RNA Interference, RNA, Messenger, metabolism, RNA, Small Interfering, Virus Diseases

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          Abstract

          RNA interference (RNAi) was discovered less than a decade ago and already there are human clinical trials in progress or planned. A major advantage of RNAi versus other antisense based approaches for therapeutic applications is that it utilizes cellular machinery that efficiently allows targeting of complementary transcripts, often resulting in highly potent down-regulation of gene expression. Despite the excitement about this remarkable biological process for sequence specific gene regulation, there are a number of hurdles and concerns that must be overcome prior to making RNAi a real therapeutic modality, which include off-target effects, triggering of type I interferon responses, and effective delivery in vivo. This review discusses mechanistic aspects of RNAi, the potential problem areas and solutions and therapeutic applications. It is anticipated that RNAi will be a major therapeutic modality within the next several years, and clearly warrants intense investigation to fully understand the mechanisms involved.

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          Author and article information

          Journal
          17449137
          1978219
          10.1016/j.addr.2007.03.005

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